Study On The Relationship Between ER、PR、Ki-67、CA12-5and Adenomyosis

Objective: Through the detection of ER, PR, Ki-67in patients with uterine glandularmyopathy in ectopic and expression of adenomyosis lesions area in the organization, detectedthe levels of blood plasma CA12-5, discuss them with the uterine adenomyosis and therelationship between the clinical manifestations.Methods: Using immunohistochemical staining EnVision two steps to detect68cases ofpatients with uterine glandular myopathy in ectopic, adenomyosis lesions area tissue and15cases with cervical CIN2, CIN3, cervical adhesion whole uterine hysterectomy patients in theER, PR in endometrium tissue, the expression of Ki-67, using photochemical light detectedthe levels of blood plasma CA12-5, VAS digital scoring method is used to assess AM patientswith dysmenorrhea degree, using color doppler ultrasound measurement uterine cavity of thevarious lines and calculate the volume and ARSM correction endometriosis in installmentmethod (1997) to evaluate the intraoperative seen pelvic cavity, and compare the relationshipbetween them.Rsults:(1) ER, PR, Ki-67in AM in ectopic, in normal endometrial lesions to organize andcontrol group all have varying degrees of positive expression.(2) ER, PR expression in theexperimental group lesion area <group in ectopic group and control group in theendometrium (P <0.05), the expression of the lining of the reign of the experimental groupand control group in ectopic, no difference (P>0.05); The expression of ER and PR inexperimental group lesions had no difference (P>0.05); Ki-67expression in theexperimental group lesion area> experimental group in ectopic group and control group inthe endometrium (P <0.05), in the lining of the reign of experimental group and control groupin ectopic expression of no difference (P>0.05).(3) the experimental group in the expressionof ER and PR in endometrium hyperplasia> for secretory phase (P <0.05), Ki-67onproliferation and secretory expression difference (P>0.05),(4) the experimental lesion areain the organization the expression of ER and PR, Ki-67in hyperplasia stage and secretorystage has no obvious difference (P>0.05). Lesions of ER, PR, Ki-67stage in hyperplasia ofthe expression and secretion of no significant change, namely no periodic change.(5), ER, PRin endometrium, lesion area in the organization of the reign of the experimental group andcontrol group in the intima hyperplasia in the period of express no difference (P>0.05); Ki-67in the lining of the reign of the experimental group and control group in ectopic expressionof no difference (P>0.05), and lesion area in the experimental group in ectopic tissuehyperplasia in the period of the expression of difference (P <0.05) in the experimental grouplesion area in the organization and the control group were differentially expressed inendometrial hyperplasia in stage (P <0.05),(6) the expression of ER and PR and Ki-67wasmoderately correlated, and the degree of pain, uterine volume, ARSM score no correlation.CA12-5and the degree of pain, uterine volume, the ASRM presents score was moderatelycorrelated, the degree of pain and uterine volume, ARSM no correlation between each other.Conclusion:1, ER, PR, Ki-67in normal endometrium, AM in ectopic, lesion area are expressed in the organization, showed that the ER, PR, Ki-67is involved in the occurrenceand development of AM process; ER, PR in the express no difference of AM lesion area,specification and cannot be determined in the process of the occurrence of AM there aredifferences in their role.2, ER and PR in AM in ectopic expression of proliferation period>secretory, explained the regulation function of lining by hormones, growth is cyclical change.In stage lesions area proliferation and secretion of the expression of indifference, that ectopicto intimal lesion area lost cyclical change, change its growth may not be completely isregulated by the E and P.3, Ki-67in AM in hyperplasia of endometrium and lesion area inthe organization and secretory expression of indifference, illustrate its no periodic change,lining in the active proliferation state, more strong proliferation after invading muscularispromoted the disease occurrence and progress. But the Ki-67used to evaluation index ofgrowth and development of AM needs further research.4, the expression of ER and PR inAM in ectopic> AM lesion area organization and normal in ectopic indifference, that AMlesion area lining on the degree of control the reaction of E and P are not consistent, may notbe in ectopic is sensitive to the reaction of the hormone and no periodic change.5, theexpression of ER and PR, Ki-67, there is a correlation between each other, E, P receptorsand cell proliferation in the process of the onset of AM has certain interactions, but thecomplex interaction still needs further research and discussion., CA12-5, and6AM inpatients with dysmenorrhea degree, size of uterus and endometriosis staging all exists certainrelevance, he can be used to evaluate the degree of pathological changes of AM, its detectionof AM auxiliary diagnosis and observe the progress of the disease has important clinicalsignificance.