Analysis Of The Changes And Clinical Significance Of Calcium And PTH After Total Thyroidectomy

Objective: To analyze the changes regularity of calcium and parathyroid hormone after total thyroidectomy, and analyze the value of parathyroid hormone in the postoperative first day predicting the hypocalcemia.Methods: We selected 100 patients who had total thyroidectomy from 2013.6 to 2014.6 in the Department of Breast and Thyroid Surgery in the Affiliated Hospital of Qinghai University, all patients before operation were not receiving any treatment about calcium supplement, parathyroid hormone and calcium were tested in the early morning and fasting before the surgery and 1 day after surgery, We continued to monitor calcium in the second、third and fifth days after operation, observed the symptoms and manifestations carefully and recorded timely.Results: Among the 100 patients undergoing total thyroidectomy, the incidence of postoperative hypocalcemia was 68%, including 46% had symptoms, the serum calcium value in the second day after the operation was the lowest[(1.86±0.14)mmol/L];the parathyroid hormone in postoperative first day for hypocalcemia patients groups[(14.03±6.01)pg/ml]were lower than the normocalcemic patients groups[(29.31 ± 12.33)pg/ml],and the difference was statistically significant(p<0.001);it was more prone to hypocalcemia when the parathyroid hormone in postoperative first day less than 15pg/ml(p<0.05);the sensitivity and specificity to predict hypocalcemia were 72.2%and 89.1% when the parathyroid hormone in postoperative first day was less than 15.85 pg / ml.Conclusions: The parathyroid hormone in the first day after total thyroidectomy can predict hypocalcemia, but the specificity and sensitivity are not very high; Hypocalcemia is associated with the reduction of parathyroid hormone; Calcium supplementation after operation can prevent the calcium to further reduce.