Clinical Observation On Treating H.pylori Gastritis Of Spleen-stomach Dampness-heat Type By Self Made "Pingwei Xiexin Tang"

Objective: To observe the clinical effect of Pingwei xiexin tang combined with bismuth quadruple in the treatment H.pylori gastritis of spleen-stomach damp-heat type,so as to provide the exact clinical basis for the treatment of H.pylori gastritis with spleen-stomach damp-heat type.Methods:Randomly 60 patients met the inclusion criteria of H.pylori gastritis of spleen-stomach damp-heat type were divided into treatment group and control group,30 cases in each group.The control group was treated with bismuth quadruple therapy: Rabeprazole Sodium Enteric-coated Capsules 20 mg,QD,before breakfast service;Bismuth potassium Citrate Capsules 0.3g,TID,take half an hour before meals;Amoxicillin Capsules 1000 mg,bid,morning and evening meal service;Clarithromycin Tablets 500 mg,bid,sooner or later after meals.The treatment group was treated with "Pingwei xiexin tang" on the basis of the control group,14 times a day and two times orally,and the two groups were treated for two days.4 weeks after treatment,the clinical symptoms,the rate of H.and pylori eradication,the improvement of gastroscopy and pathology,and the incidence of adverse events during the treatment were observed.The data were analyzed statistically.Result:(1)The overall curative effect: the total effective rate of the treatment group was up to 86.7%,and the total effective rate of the control group was 70%.The total effective rate of the treatment group was significantly better than that of the control group,the difference was statistically significant(P<0.05).(2)TCM symptom score: two groups of the total scores of symptoms before and after treatment significantly decreased,the difference was statistically significant(P<0.05),total score of symptoms after treatment in the treatment group than the control group,the difference was statistically significant(P<0.05).The main symptoms and secondary symptoms score,the treatment group in the epigastric fullness,belching and acid regurgitation,eating less pain and loose stool symptoms than the control group,the difference was statistically significant(P<0.05).(3)The eradication rate of H.pylori: the treatment group of 27 patients were negative,H.pylori eradication rate was 90%,22 cases of control group were negative,H.pylori eradication rate was 73.3%.The eradication rate of H.pylori in the treatment group was better than that in the control group,and the difference was statistically significant(P<0.05).(4)Comparison of gastroscopy and pathology of curative effect: the two groups 4 weeks after treatment by gastroscope curative effect comparison,was statistically significant(P<0.05);4week end pathological effect after the treatment in the two groups,with statistical significance(P<0.05),showed that the improvement was significantly higher than the control group the treatment group of gastroscopy and pathological effect.(5)The incidence of adverse reactions: the incidence of adverse reactions in the control group was 23.3%,the incidence of adverse reactions in the treatment group was 3.3%,and the incidence of adverse reactions in the control group was significantly higher than that in the control group.Conclusion: Director Wang Yuzhu use "detoxification,spleen dampness","Pingwei xiexin tang" combined with bismuth quadruple therapy to treat H.pylori gastritis of spleen-stomach damp-heat type can effectively improve the clinical symptoms of patients,improve the eradication rate of H.pylori,improve the gastroscopic and pathological inflammatory manifestations of H.pylori gastritis patients,and reduce the adverse reaction rate caused by the use of medicine.