Associations Between Hepatic And Renal Markers And Type 2 Diabetes Mellitus Among Chinese Adults

Aim: Liver and renal functions are highly associated with occurance of type 2 diabetes mellitus(T2DM)but the predictive values of serum markers of liver and renal function for development of T2 DM remains not fully clear.Therefore,this study aimed to investigate the correlation between serum hepatic and renal markers(alanine aminotransferase,ALT;aspartate aminotransferase,AST;total bilirubin,TBil;creatinine,Cr;blood urea nitrogen,BUN)and prevalence of type2 diabetes mellitus in Binhai strict,Tianjin.Methods: A total of 4070 subjects between 59 and 95 years of age in a community-based natural population were enrolled in the study and were tested for the following serum biochemical parameters,including ALT,AST,TBil,Cr,BUN,TC,TG and blood glucose.All subjects were divided into fourgroups(Q1-Q4)according to the quartiles of ALT,AST,TBil,Cr,BUN levels.Logistic regression was performed to explore the odd ratios(ORs)(95%CI)for the prevalence of T2 DM in groups of Q2-Q4 compared with the group of Q1,with adjustment for age,BMI,smokeing status,drinking intake and the history(CVD,Hypertension,Diabetic,Hyperlipemia).Results: The prevalence of T2 DM was 12.7% for the whole population,and 8.6% and 16.2% for males and females,respectively.Different hepatic markers have distinctive associations with T2 DM in general population.Similar relations were observed in different adjusted models.After adjustments for all potential confounding factors,the odds ratios(95% confidence interval)of the prevalence of T2 DM by quartiles of hepatic markers levels were as follows: 1.When the quartiles were defined by the ALT level,compared with the group of Q1,the OR for the group of Q2-Q4 were 1.11(0.95,1.31),1.21(1.02,1.44),1.6(1.35,1.89)(P for trend <0.01),1.25(1.06,1.48),1.21(1.02,1.44),1.33(1.15,1.63)(P for trend <0.01)and 0.91(0.72,1.01),1.31(0.93,1.59),1.86(1.46,2.39)(P for trend <0.01)in the males and females,respectively.2.When the quartiles were defined by the AST level,no significant associations was observed.Compared with the group of Q1,the ORs for the group of Q2-Q4 were 0.76(0.66,0.89),0.62(0.53,0.72),0.87(0.74,1.03)(P for trend =0.55),0.86(0.75,0.99),0.56(0.44,0.79),0.76(0.66,0.1.03)(P for trend =0.09)and 0.65(0.54,1.12),0.76(0.66,1.08),0.93(0.88,1.56)(P for trend =0.65)in the males and females,respectively.3.The significant association between TBil and T2 DM was only observed in total population.Compared with the group of Q1,the ORs for the group of Q2-Q4 were0.98(0.86,1.14),0.89(0.78,0.96),0.90(0.80,0.98)(P for trend =0.04)4.There were no significant associations in both genders for Cr and BUN.Conclusion: The results showed that different hepatic markers have distinctive associations with T2 DM in general population,independent of other confounding factors.It is necessary to conduct more studies focusing on the relationships between liver condition and T2 DM and explore the underlying mechanisms.