Clinical Observation Of Huoxiang Qinghua Decoction In Treating Hp-associated Chronic Non-atrophic Gastritis With Spleen And Stomach Damp-heat

Objective: This study observed the clinical efficacy and safety of Huoxiang Qinghua decoction for the treatment of Hp-associated chronic non-atrophic gastritis with spleen and stomach damp-heat syndrome.And compared with standard triple therapy,discussed the advantages and disadvantages of traditional Chinese medicine(TCM)in treating this disease,aiming to provide objective evidence for the clinical treatment of Hp-associated chronic non-atrophic gastritis with TCM.Methods: 64 patients of Hp-associated chronic non-atrophic gastritis with spleen and stomach damp-heat who met the inclusion criteria were selected and divided into two groups by random number table method,32 cases in each of the treatment group and the control group.The treatment group was treated with oral Huoxiang Qinghua decoction,and the control group was treated with oral standard triple therapy(omeprazole sodium bicarbonate capsules + amoxicillin dispersible tablets + clarithromycin sustained release tablets).Subjects in both groups were treated for two weeks,followed by a review of the 14C-urea breath test in four weeks after withdrawal.The curative effect of TCM syndrome,TCM symptom scores,Helicobacter pylori eradication rate and adverse reactions of the two groups were observed before and after treatment.Patients in the treatment group who didn’t alleviate their disease or weren’t satisfied with the curative effect after treatment were given extension of two weeks for consolidation treatment,and the eradication rate of Helicobacter pylori before and after prolonged treatment was compared.Statistical software was used to analyze the data.Results:1.Comparison of total clinical symptom scores: There was no statistical difference in total score of clinical symptoms between the two groups before treatment(P>0.05).After treatment,the total clinical symptom scores of the two groups were significantly lower than before treatment,and the treatment group was better than the control group,with statistically significant differences(P<0.05).2.Comparison of single symptom scores: After treatment,all symptoms in the treatment group were significantly improved than before treatment(P<0.05),while symptoms of stool stickiness in the control group didn’t improved(P>0.05).The curative effect of the treatment group was significantly better than the control group in improving the symptoms of stomach fullness,dry and bitter mouth,bad breath,less appetite,stool stickiness(P<0.05).There was no statistically significant difference in improving the symptoms of acid reflux betwee the two groups of curative effect(P>0.05),and the control group was better than the treatment group in improving the symptoms of epigastric pain(P<0.05).3.Comparison of curative effect of TCM syndromes: After treatment,the effective rate was 86.7% in the treatment group,among them,four cases were cured,fifteen cases were markedly effective,seven cases were effective and four cases were ineffective.The effective rate was 70.0% in the control group,among them,three cases were cured,six cases were markedly effective,twelve cases were effective,nine cases were ineffective.Indicating that the TCM syndromes’ effective rate of the treatment group was significantly better than the control group,and the difference was statistically significant(P<0.05).4.Comparison of Helicobacter pylori eradication rates: Helicobacter pylori eradication rates in the treatment group was 36.66%,whith in the control group was 76.66%,the treatment group was lower than the control group,and the difference was statistically significant(P<0.05).Helicobacter pylori eradication rate of 14 patients in the treatment group increased from 28.57% to 64.29% after prolonged treatment,but the difference was not statistically significant(P>0.05).5.Safety comparison: No serious adverse events occurred during the treatment of the two groups.The safety indicators(blood,urine,fecal routine as well as liver and kidney function)before and after treatment in the two groups were not significantly abnormal,indicating that the treatment method was relatively safe.Conclusions: Huoxiang Qinghua decoction is superior to standard triple therapy in improving the patients’ clinical symptoms of Hp-associated chronic non-atrophic gastritis with spleen and stomach damp-heat syndrome,and the safety is good.But the eradication effect of Helicobacter pylori is not obvious,the Helicobacter pylori eradication rate is lower than that of standard triple therapy.