Clinical Study Of Self-made Kidney-warming Moxibustion On Chronic Kidney Disease With Deficiency Of Yang And Deficiency Of Kidney Yang

Objective: This study is based on the "three differentiation" model of body differentiation,disease differentiation and syndrome differentiation to treat patients with kidney yang deficiency syndrome of chronic kidney disease with yang deficiency.The main purpose of this study is to observe and study the clinical efficacy and safety of self-made kidney moxibustion on kidney yang deficiency syndrome of chronic kidney disease and its effect on related indexes,and to observe the changes of thyroid hormones in patients with kidney yang deficiency syndrome of chronic kidney disease of yang deficiency.To explore the relationship between yang deficiency,chronic kidney disease and thyroid hormone,and the mechanism of self-made kidney-warming moxibustion on kidney-yang deficiency syndrome of chronic kidney disease.By improving the constitution of Yang deficiency and then controlling the development of chronic kidney disease,it provides a theoretical basis for the treatment of chronic kidney disease by external treatment of traditional Chinese medicine.Methods: the study was randomly divided into two groups with a single blind method.72 patients who met the inclusion criteria were selected,and 61 patients completed the study,including 31 patients in the treatment group and 30 patients in the control group.The control group was treated with routine symptomatic treatment plus moxibustion with clearing moxa strips,and the treatment group was treated with routine symptomatic treatment plus self-made kidney-warming moxibustion with mild moxibustion.Self-made moxibustion for warming kidney: moxa sticks for warming kidney were made by mixing the fine powder of moxa strips with cinnamon,cloves and aconite in the proportion of 3:1:1:1.Gently moxibustion bilateral Shenshu acupoints,Mingmen acupoints,Qihai acupoints,Guanyuan acupoints,bilateral Zusanli acupoints.Moxibustion15 min at each acupoint.Once a day,6 times a week,4 weeks as a course of treatment,a total of 3 courses of treatment.Use statistical methods to analyze and compare the total efficacy of the two groups before and after treatment,TCM syndrome efficacy,TCM physique transformation scores,related laboratory indicators,safety indicators changes,and finally get the results.Results: 1.Basic data: 61 patients who met the inclusion criteria were enrolled in this study.there was no significant difference in sex,age,course of disease,TCM syndrome score,renal function,glomerular filtration rate,thyroid function and TCM physique transformation score between the two groups before treatment((P > 0.05).2.Total effective rate: after treatment,the total effective rate of the treatment group and the control group was 87.1% and 73% respectively,and the difference between the two groups was statistically significant(P < 0.05).3.TCM syndrome score and TCM constitution transformation score: in the treatment group and the control group in improving TCM syndrome and Yang deficiency constitution,the curative effect of self-made kidney-warming moxibustion intervention group was better than that of the control group(P<0.05),which was statistically significant.4.Laboratory indexes: after treatment,24-hour urinary protein,serum creatinine,blood urea nitrogen,glomerular filtration rate,thyrotropin,thyroid hormone and triiodothyronine in the two groups were significantly different from those in this group before treatment(P<0.05,P<0.01).The improvement of serum creatinine,blood urea nitrogen,glomerular filtration rate,thyrotropin and triiodothyronine in the treatment group were significantly better than those in the control group(P<0.05,P<0.01).5.In terms of safety indicators,there were no obvious adverse reactions in the treatment group and the control group before and after clinical treatment,so the safety of this study should be affirmed.Conclusion: self-made kidney-warming moxibustion has a good clinical effect in the treatment of stage 3 and 4 chronic kidney disease with Yang deficiency constitution.The improvement of TCM clinical syndrome,the conversion score of yang deficiency,serum creatinine,blood urea nitrogen,glomerular filtration rate,thyrotropin and triiodothyronine in the control group were superior to those in the control group,indicating that moxibustion can effectively improve the constitution of yang deficiency.The effect of self-made moxa strip moxibustion group in correcting yang deficiency constitution is better than that of Qing moxa strip group,the constitution tends to be peaceful,and the body yin and yang are coordinated.While recuperating the physique,it can also regulate thyroid dysfunction,reduce the interaction between thyroid dysfunction and chronic kidney disease,and then effectively delay the development of CKD,better improve the clinical symptoms of patients,and improve the quality of life of patients.