| Objective:Poor ovarian response(POR)is one of the common cause of failure of in vitro fertilization embryo transfer(IVF-ET)there is currently no recognized and effective treatment strategy to improve ovarian response to ovulation-promoting drugs to ovulation-promoting drugs.This topic is to study the clinical effect of Bushen Huoxue Fang on POR patients treated with microstimulation.It will open up new ideas and methods for clinical treatment of POR.Methods:Forty-five POR patients meeting the inclusion criteria were randomly divided into a treatment group(Bushen Huoxue Fang+Western medicine micro-stimulation)30 cases and a control group(Western medicine micro-stimulation)15 cases according to 2:1.To observe endometrial thickness on the day of HCG injection,ovulation success rate,mid-luteal estrogen and progesterone levels,clinical pregnancy rate,and biochemical pregnancy rate in the two groups;Also to compare the levels of basal follicle stimulating hormone(bFSH),the ratio of basal follicle stimulating hormone to basal luteinizing hormone(bFSH/bLH),basal estradiol(bE2),sinus follicle counts(AFC),and TCM symptoms before and after treatment between two groups.Results:(1)Comparison of ovulation:The treatment group was treated for 90 menstrual cycles,including 33 ovulation cycles with an ovulation rate of 36.67%.The control group treated 45 menstrual cycles,including 9 ovulation cycles with an ovulation rate of 20.00%.The ovulation rate in the treatment group was higher than that in the control group.The difference was statistically significant(P<0.05).(2)Comparison of estrogen and progesterone levels in the mid-luteal phase:After 7 days of ovulation,the E2 and P levels in the treatment group were higher than those in the control group,the difference was statistically significant(P<0.05).(3)Comparison of endometrial thickness on the day of HCG injection:The treatment group was 8.67 ± 0.63mm;the control group was 7.14 ± 0.44mm.The endometrial thickness of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.01).(4)Comparison of pregnancy outcomes:The clinical pregnancy rate in the treatment group was 10.00%,and the clinical pregnancy rate in the control group was 6.67%.The clinical pregnancy rate in the treatment group was higher than that in the control group,but the difference was not statistically significant(P>0.05).1 case of biochemical pregnancy in the treatment group,biochemical pregnancy rate of 3.33%.The biochemical pregnancy phenomenon was not followed up in the control group.Due to the small number of cases,statistical analysis was not possible.(5)Comparison of TCM symptom scores:Before treatment,there was no significant difference in TCM symptom scores between the two groups(P>0.05).After treatment,the TCM syndrome scores of the treatment group were significantly lower than those before treatment,and the difference was statistically significant(P<0.01);the TCM syndrome scores of the control group were not statistically significant compared with those before treatment(P>0.05);the TCM symptom scores of the treatment group were significantly lower than those of the control group,and the difference between the two groups was statistically significant(P<0.01).The difference of the TCM symptom scores of the treatment group before and after treatment was significantly higher than that of the control group,and there was a statistically significant difference(P<0.01).(6)Comparison of ovarian reserve indexes:Before treatment,there was no statistical difference between the two groups of ovarian reserve indexes(P>0.05).After treatment,the bFSH level,bFSH/LH ratio,bE2 level in the treatment group were decreased compared with before treatment,and the AFC count in the treatment group was increased compared with before treatment,the differences were statistically significant(P<0.05);the bFSH level,bFSH/LH ratio,bE2 level and AFC count of the control group were not statistically different from those before treatment(P>0.05);compared with the control group,the bFSH level,bFSH/LH ratio,and bE2 level decreased,and the AFC count increased in the treatment group,the differences were statistically significant(P>0.05).As ovarian reserve declines,inhibin secretion decreases,and the inhibitory effect on pituitary secretion of FSH is weakened.Higher levels of FSH recruit residual follicle growth and development in advance,resulting in increased E2 level in the early follicular phase.Therefore,the level of bE2 level decreases after treatment.Conclusions:1.Bushen Huoxue Fang plays a benign role in regulating HPOA axis in patients with POR,effectively reducing bFSH levels,bFSH/LH ratio,and bE2 levels,increasing the number of sinus follicles,to improve ovarian reserve function in patients with POR,and increase the ovulation rate of Ovulation-promoting cycle.2.Bushen Huoxue Fang can effectively alleviate the inhibition of ovulation-promoting drugs on endometrial growth,and to a certain extent improve the pregnancy rate of patients with POR.3.Bushen Huoxue Fang can effectively alleviate the symptoms of kidney deficiency and blood stasis in POR patients,thereby improving their quality of life. |
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