Analysis And Clinical Significance Of Serum Cystatin C Level In Premature Infants

Objective:By detecting the level of serum cystatin C in 166 premature infants,to understand the level of serum cystatin C in premature infants,and to explore the effect of disease on the level of serum cystatin C in premature infants,to provide reference indexes for early assessment of renal function in premature infants.Methods:A total of 166 premature infants who were admitted to the neonatal department of our hospital from February 2019 to December 2019 and met the inclusion criteria were included in the study.According to the presence or absence of comorbidities after admission,they were divided into a comorbidity group(83 cases)and a no comorbidity group(83 cases).The no comorbidity group was further divided into very prematerm group,moderate preterm group,and late preterm group according to different gestational ages;according to the relationship between birth weight and gestational age,it was divided into SAG?AGA and LGA.According to different critical illness scores,the comorbidity group was divided into extremely critical group?critical group and non-risk recombination.All neonates completed the blood collection within 2 hours after admission and before the milk was opened,and the neonatal serum cystatin C(Cys C),serum urea nitrogen(BUN),and serum creatinine were analyzed using ysmex XE-2100TM automatic analysis detector SCr).SPSS 17.0 statistical software was used for data analysis.Results:1.No premature babies in the comorbidity group and no comorbidity group had renal injure;2.Comparison of the general conditions between the groups:there is a statistically significant difference in the birth weight of preterm infants with different gestational ages in the uncomplicated group(P<0.001),and the birth weight between the three groups is statistically significant(P<0.05),but there was no statistically significant difference in gender,mode of delivery and parity(P>0.05);there was no statistically significant difference in sex,gestational age,mode of delivery and parity in preterm infants with different developmental status in the no comorbidity group Significance(P>0.05);the gestational age of the no comorbidity group was greater than that of the comorbidity group,the difference was statistically significant(P=0.032);the number of cesarean section in the comorbidity group was significantly higher than that in the no comorbidity group,and the difference was statistically significant(P=0.012),and there was no significant difference in gender,birth weight and parity between the two groups(P>0.05);the gender,birth weight,gestational age and delivery method of preterm infants with different critical illness scores is no statistical significance in the comparison of parity(P>0.05);3.Comparison of serum Cys C,SCr and BUN in preterm infants with different gestational ages:The levels of serum Cys C in very premature group,moderate preterm group,and late preterm group were(2.26±0.32)mg/L,(2.09±0.26)mg/L,(1.87±0.21)mg/L,the three groups are higher than the normal reference value range of our hospital(0.59-1.03)mg/L,and the difference between the each other group is statistically significant(P=0.011),The difference between the two groups was statistically significant;the difference between SCr and BUN in each group was not statistically significant(P>0.05);4.Comparison of serum Cys C,SCr and BUN of premature infants with different developmental conditions:The levels of serum Cys C in SGA group,AGA group and LGA group were(1.85±0.17)mg/L,(2.00 ±0.22)mg/L,(2.06±0.24)mg/L.Serum CysC level of the three groups is higher than the normal reference value range of our hospital(0.59-1.03)mg/L.The difference between the three groups is statistically significant(P=0.049).In the two comparisons,only the serum CysC of LGA groups and SGA group had statistically significant differences(P<0.05);the levels of SCr in the SG A group,AGA group,and LG A group were(71.23±17.26)umol/L,(64.46±12.37))Umol/L,(55.09±9.93)umol/L,the three groups are within the normal reference value range of our hospital(70.72?123.76)umol/L,the difference between the three groups is statistically significant(P<0.001),and Comparison between the three groups,SGA group>AGA group>LGA group,the difference was statistically significant(P<0.05);SGA group,AGA group,LGA group BUN difference was not statistically significant(P=0.881);5.Comparison of serum Cys C,SCr and BUN between no comorbidity group and comorbidity group:Cys C level in no comorbidity group was(1.97±0.21)mg/L,Cys C level in the comorbidity group was(2.29±0.22)Mg/L,the difference in Cys C between the two groups is statistically significant(P<0.001);the difference in SCr and BUN between the two groups is not statistically significant(P>0.05)6.Comparison of serum Cys,SCr and BUN in preterm infants with different critical illness scores:the levels of Cys C in the extremely critica group,critical group and non-risk group were(2.42±0.18)mg/L and(2.13 ± 0.17)mg,respectively./L,(2.06±0.20)mg/L,the difference between the three groups was statistically significant(P<0.001),the two groups were compared between two groups,extremely critica group>critical group>non-risk group,extremely critically reorganized The difference between dangerous and non-risk reorganization was statistically significant(P<0.05),but the difference between critical group and non-risk reorganization was not statistically significant(P>0.05);there was no statistically significant difference between the three groups of SCr and BUN(P>0.05)?Conclusion:1.The level of serum Cys C in all preterm infants in this study was higher than the normal reference value range,but no renal function damage occurred;2.The lower the gestational age of premature infants,the higher the level of serum Cys C may be,suggesting that the smaller the gestational age of premature infants,the more immature the development of renal function;3.This study suggests that the level of serum Cys C in the comorbidities preterm infants is higher than that of no comorbidities preterm infants,which may be related to the small gestational age and disease of premature infants with disease;4.The level of serum Cys C in premature infants increases with the severity of the disease.