The Analysis Of Relationship Between Skin Moisture And Epidermal Structure In Facial Skin Rejuvenation In Healthy Han Subjects

Background The skin barrier is the outermost protective layer in direct contact with the outside world.In many skin diseases,the skin barrier is damaged due to various reasons,such as acne,seborrheic dermatitis,and allergic dermatitis.Skin physiological indicators have changed,and skin moisture is also different.Transepidermal water loss(TEWL)and stratum corneum hydration(SCH)can be used not only to judge the severity of the disease,but also to help diagnose and treat the disease.There were significant changes in transepidermal water loss and epidermal water content between different age groups.Quantitative analysis was used to analyze the correlation between skin physiological status and epidermal thickness and density,and objectively quantify the degree of facial skin rejuvenation and aging.Objectives Noninvasive detection technology was used to quantify facial skin water loss and water content in healthy Han people of different ages,and analyze the correlation between moisture and skin structure(density and thickness).Explore the role and significance of results in facial rejuvenation.Methods 846 Chinese Han volunteers were randomly selected and divided into six groups according to age group(0-2 years;3-12 years;13-18 years;19-45 years;46-65years;65 years and over).The subjects used non-invasive physiological testing instruments to measure the transepidermal water loss(TEWL)and cuticle water content(SCH)of the forehead and cheeks,and measured the epidermal density and thickness of the forehead and cheeks with skin ultrasound.The correlation was analyzed by statistical methods.Results1.With the increase of age,the thickness of the facial epidermis first increases,and then decreases relatively smoothly or slowly,while the density of the epidermis gradually decreases.Facial transepidermal water loss continues to increase,and skin epidermal water content decreases.Significant differences were found in the thickness of the epidermis,the density of the epidermis,the amount of transepidermal water loss,and the moisture content of the epidermis between the forehead and cheek.The forehead is more capable of retaining and losing water than the cheeks.2.Overall,in Chinese Han healthy population,the epidermal water content is negatively correlated with epidermal thickness,transepidermal water loss,and epidermal density.Transepidermal water loss is proportional to epidermal thickness,epidermal water content,and epidermal density.This is most pronounced during adolescence.The forehead epidermal water content was significantly correlated with the thickness of the epidermis,r =-0.429,and the regression equation was y =-4.337 x + 378.81.The amount of transepidermal water loss on the cheek was significantly related to the density of the epidermis,r =-0.534,and the regression equation was y =-10.683 x +266.13.The correlation between the water content of the cheek epidermis and the density of the epidermis was not obvious.Conclusion There are differences in facial skin moisture and epidermal thickness and density in different age groups of Chinese Han people.The ability of the skin to lock and dehydrate is significantly related to the structure of the epidermis.Non-invasive detection methods can be used to quantitatively evaluate the degree of facial skin rejuvenation.