Application Of Genetic Testing In Hypertension Patients In Rural Areas Of Anhui Province

Objective This study,for the first time,combined individualized drug detection with family doctors' contracting model,to assess the application of precision medicine in rural patients with essential hypertension.Methods In this study,209 hypertensive patients from 3 villages in Lujiang County,Hefei City,Anhui Province were selected as subjects and randomly divided into control group(n=105)and experimental group(n=104).The medication regimen of observation group was guided by genetic testing for gene sensitivity to antihypertensive drugs,and the control group implemented routine management.All the patients were managed by family doctor.Adverse drug reaction rate,treatment compliance blood pressure values,body mass index(BMI),fasting blood glucose(FBG),cholesterol(TC),and triglycerides(TG)of the two groups were analyzed,respectively,during the 6-month intervention period.Results After 6 months of intervention,the medication compliance and blood pressure control rate of the experimental group were significantly higher than that of the control group,and the adverse drug reaction rate was significantly lower than that of the control group.And adverse drug reaction rate was basically sTab after 3 months.After 3 months of intervention,there was no significant decrease in BMI,FBG,TC and TG in the two groups.After 6 months of intervention,the FBG,TC and TG of the experimental group were significantly decreased,and only the FBG value of the control group was significantly decreased.There were no significant changes in BMI values in all the patients.Conclusion The family doctor contract service model can improve the treatment compliance and blood pressure control rate of patients with essential hypertension in rural areas,which can probably make great contribution to the prevention and control of essential hypertension in rural areas.