| Objective:By observing the clinical effect of treating knee osteoarthritis of cold and dampness arthralgia and analyzing the etiology and pathogenesis of knee arthralgia in middle-aged and old people,the clinical treatment experience of knee arthralgia is summarized to provide clinical ideas for the treatment of knee osteoarthritis in middle-aged and old people.Methods:①Middle-aged and elderly patients with cold-dampness obstruction knee osteoarthritis who met the diagnosis,inclusion criteria and exclusion criteria in the outpatient department of Jiangsu Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from November 2020 to February 2021 and who volunteered to participate in the study were collected.②The 48 patients were divided into experimental group(24 cases)and control group(24 cases)for clinical observation.③The experimental group was given "Xibining" decoction for oral treatment,and the control group was given celecoxib capsule for oral treatment,with a course of 4 weeks.④Womac score of knee joint,VAS pain score,total score of TCM symptoms,single score of TCM main symptoms and secondary symptoms were observed before and after treatment,and statistical analysis was conducted to determine the exact efficacy of the two treatment methods.SPSS26.0 statistical software was used to analyze the relevant scale score,disappearance rate of primary and secondary symptoms,total response rate and BMI data of the two groups of cases.The collected measurement data were tested for normal distribution.If they were in line with the normal distribution,they were expressed as mean±standard deviation(X±S),and t-test or one-way analysis of variance was used.If not,the median and upper and lower quartiles were used to represent,and the non-parametric test rank sum test was used to test.Test results are expressed as P value,P<0.05 indicates that the difference is statistically significant;otherwise,it is not.Results:①Comparison of general data:age,gender,course of disease,BMI and pre-treatment related symptom scores were compared between the two groups(P>0.05)The difference was not statistically significant,but was comparable.②Comparison of clinical symptom scores:After treatment,it was found that both of the two methods had certain clinical efficacy,and the clinical efficacy of the two groups was similar in improving joint pain.In terms of improving joint function,the efficacy of the experimental group was similar after 2 weeks of treatment,and the efficacy of the experimental group was better than that of the control group after 4 weeks of treatment.In terms of TCM symptoms,the two groups had the same effect on the three main symptoms and one stiff symptom,but the improvement of the three symptoms in the experimental group was significantly better than that in the control group(P<0.05).③Comparison of clinical efficacy:after the complete course of treatment,the total effective rate of the experimental group was 87.5%,higher than that of the control group(54.1%),through the rank sum test(P<0.05).④ Safety comparison:Before and after treatment,there were no adverse reactions including vital signs,such as allergy or systemic toxic reactions,and the safety was high in both groups.Conclusion:①Both Qiubining Decoction and Celecoxib Capsules can effectively treat knee osteoarthritis with cold dampness obstruction syndrome in the early and middle stages,and the incidence of adverse reactions is low.②Xiu Bining Decoction and Celecoxib Capsules have the same efficacy in improving the pain of patients with knee osteoarthritis of cold dampness obstruction type in the early and middle stages.③Xiu Bining has a high overall effective rate in the treatment of knee osteoarthritis with cold and dampness obstruction in the early and middle stages.It is more effective than celecoxib in the treatment of joint function and the three traditional Chinese medicine symptoms of waist and knee acid and soft,aggravation of cold and joint weight,which is worthy of clinical promotion and use. |
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