| ObjectiveBy observing the clinical efficacy of modified Huangqin decoction combined with Me-salazine suppository in the treatment of mild to moderate ulcerative proctitis(damp-heat downward injection),to explore the curative effect and clinical value of modified Huangqin d-ecoction,and to adop-toral administration combined with external use.And the use of tradit-ional Chinese and western medicine in the treatment of ulcerative proctitis,and strive to see-k a more effective treatment of ulcerative proctitis.MethodsSeventy-two patients with ulcerative proctitis were randomly divided into treatment gr-oup(n=36)and combined treatment group(n=36).Among them,the treatment group was only treated with mesalazine suppositories,and the patients in the combined treatment group were treated with oral Huangqin decoction combined with Mesalazine suppositories.The tr-eatment period was 1 month.The total score of TCM symptoms and the scores of each sym-ptom(diarrhea score,mucus purulent and bloody stool score,abdominal pain score,inexhau-stible stool score,anal distension score,anal burning se-nsation score),Baron score,Mayo score and IBDQ score)were recorded before and after treatment.The overall therapeutic effe-ct,changes of main c-oncomitant symptoms,enteroscopic mucosa,activity and quality of lif-e were observed in the two groups before and after treatment.Quantification and statistical analysis were carried out.ResultsThere were 4 cases in the treatment group and 4 cases in the combined treatment group,and a total of 64 patients participated in the data analysis.The baseline data(age,sex,course and degree of disease)of the two groups were comparable(P>0.05).(1)The overall comparison of TCM symptoms between the two groups:after treatment,the effective rate of the treatment group was 71.87%,while that of the combined treatment group was 93.75%.In the treatment group,clinical remission was found in 0 cases,marked1y effective in 2 cases,ef-fective in 21 cases and ineffective in 9 cases.In the combined treatment group,clinical remission was found in 3 cases,markedly effective in 18 cases,effective in 10 cases and ineffective in 1 case.There was significant difference between the two gro-ups(P<0.05).(2)The scores of various symptoms in the two groups:after treatment,the scores of diar-rhea,mucous purulent and bloody stool,abdominal pain,incomplete stool,anal distension and anal burning sensation in the two groups were lower than those before treatment(P<0.05),indicating that both groups could improve the symptoms of the patients.However,throug-h the non-parametric test of two independent samples,the rank mean of each symptom in t-he combined treatment group was lower than that in the treatment group,suggesting that th-e decrease in the score of TCM symptoms in t-he combined treatment group was more obv ious than that in the treatment group.At the same time,the difference of TCM symptoms bet-ween the two groups before and after treatment was tested by two independent samples Ma nn-Whitney non-parametric test,the rank mean of the combined treatment group was highe-r than that of the treatment group,and there was a significant difference,suggesting that th-e difference before and after treatment in the combined treatment group was greater than th-at in the treatmentgroup,indicating that the improvement of various symptoms in the comb-i-ed treatment group was significantly better than that in the treatment group.(3)The Baron score of enteroscopy in the two groups:the Baron score of enteroscopy in both groups after treatment was significantly lower than that before treatment(P<0.05),indicating that both groups could reduce the Baron score of enteroscopy.There was a significant difference in the Baron score of enteroscopy between the two groups after treatment.The improvement of Baron score of enteroscopy in the combined treatment group was significantly better than that in the treatment group.(4)The overall comparison of enteroscopy between the two groups:after treatment,the effective rate of the treatment group was 78.12%,while that of the combined treatment group was 93.75%.In the treatment group,clinical remission was achieved in 1 case,markedly effective in 4 cases,effective in 20 cases and ineffective in 7 cases.In the combined treatment group,clinical remission was achieved in 10 cases,markedly effective in 10 cases,effective in 10 cases and ineffective in 2 cases.There was significant difference between the two groups by Wilcoxon rank sum test.The curative effect of the combined treatment group was significantly better than that of the treatment group.(5)Comparison of modified Mayo scores between the two groups:Mayo scores after treatment in both groups were lower than those before treatment,indicating that treatment in both groups could improve the range of activity of the disease.However,through the non-parametric test of two independent samples,the rank mean of the combined treatment group was lower than that of the treatment group,suggesting that the decrease of Mayo score in the combined treatment group was more obvious than that in the treatment group.At the same time,the difference of Mayo score between the two groups before and after treatment was tested by two independent samples Mann-Whitney nonparametric test,the rank mean of the combined treatment group was significantly higher than that of the treatment group,suggesting that the difference of the combined treatment group before and after treatment was greater than that of the treatment group,indicating that the improvement of Mayo score of the combined treatment group was significantly better than that of the treatment group in disease activity.(6)Comparison of IBDQ scores between the two groups:the quality of life of IBDQ after treatment in both groups was lower than that before treatment,indicating that treatment in both groups could improve the overall quality of life of patients.However,through the non-parametric test of two independent samples,the rank mean of the combined treatment group was lower than that of the treatment group,suggesting that the decrease of IBDQ quality of life score in the combined treatment group was more obvious than that in the treatment group.At the same time,the difference of IBDQ quality of life between the two groups before and after treatment was tested by two independent samples Mann-Whitney non-parametric test,the rank mean of the combined treatment group was significantly higher than that of the treatment group,suggesting that the difference before and after treatment in the combined treatment group was greater than that of the treatment group,indicating that the improvement of IBDQ quality of life in the combined treatment group was significantly better than that in the treatment group.ConclusionModified Huangqin decoction combined with mesalazine suppository has definite cura-tive effect on patients with mild to moderate ulcerative proctitis of damp-heat type of large intestine.it can significantly improve the TCM symptoms of diarrhea,mucous bloody stool,abdominal pain,incomplete stool,anal distension and anal burning sensation,promote inte-stinal mucosal healing,reduce activity,and improve the quality of life of patients. |
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