Clinical Observation Of Shenbai Enema Recipe In The Treatment Of Large Intestine Damp-heat Ulcerative Colitis And Its Effect On IL-1 And IL-6 Levels

ObjectiveObserve the clinical efficacy of Shenbai Enema Retention Enema in the treatment of mild to moderate ulcerative colitis of large intestine damp-heat type and its effect on IL-1and IL-6 levels.Methods60 patients were selected from September 2019 to December 2020 in the outpatient or inpatient department of the Anorectal Department and the Department of Spleen and Stomach Diseases of the Affiliated Hospital of Gansu University of Traditional Chinese Medicine.The treatment group was treated with Shenbai enema prescription retention enema,and the control group was treated with mesalazine enema retention enema.Both groups were treated for 2 cycles.To observe and compare the total effective rate of patients before and after treatment,the scores of various TCM syndromes,Mayo score,Myao endoscopy sub-score,quality of life score,and determine the serum interleukin 1(IL-1)and interleukin 6(IL-6)levels The difference.Results1 Comparison of clinical efficacy of diseases: The effective rate of the treatment group(93.4%)is higher than that of the control group(83.4%),and the difference is not statistically significant(p>0.05).The two groups have the same therapeutic effect.2 Comparison of the efficacy of TCM syndromes: After treatment,the scores of TCM syndromes in the two groups were significantly reduced(p<0.05),but the treatment group had more significant efficacy in improving diarrhea,mucus,pus and blood in the stool,and the difference was statistically significant(p<0.05),the curative effect of improving abdominal pain and tenesmus is equivalent to that of the control group,and the difference is not statistically significant(p>0.05).3 Comparison of Mayo scores: After treatment,the Mayo scores of the two groups decreased significantly,and the difference was statistically significant(p<0.01).The treatment group had a significant advantage in improving the Mayo score,and the difference was statistically significant(p<0.01).4 Comparison of endoscopy sub-scores: Mayo endoscopy sub-scores decreased significantly after treatment(p<0.01),but there was no statistically significant difference between the two groups(p>0.05).5 Comparison of quality of life: After treatment,the four dimensions of IBDQ and the total score of the two groups of patients were significantly increased(p<0.01),but the treatment group improved more significantly in the four dimensions of the score and the total score,and the difference was statistically significant(p<0.01)).6 Comparison of serum IL-1 and IL-6: After treatment,the serum IL-1 and IL-6 of the two groups were significantly decreased(p<0.01),but the treatment group had more significant improvement in serum IL-1 and IL-6,with differences Statistically significant(p<0.01).7 Comparison of recurrence rate: Through follow-up,the control group was 20%,and the treatment group was 3.4%.The treatment group was significantly lower than the control group,and the difference was statistically significant(p<0.05).8 Comparison of the incidence of adverse reactions: Serious adverse reactions occurred in both groups.ConclusionThe retention enema of Shenbai enema is effective in treating patients with mild to moderate damp-heat ulcerative colitis of the large intestine.It can effectively improve the clinical symptoms and improve the quality of life of the patients.The mechanism of the treatment of UC may be related to the inhibition of serum IL-1 and IL-6 secretion related.