Clinical Observation Of Erbai Yangzheng Decoction In The Treatment Of Chronic Non-Atrophic Gastritis (Spleen And Stomach Qi Deficiency Syndrome) After Hp Eradication

Objective: To observe the relationship between HP and its eradication treatment and the distribution of TCM syndrome types,and to further investigate the clinical efficacy of Erbai Yangzheng Decoction in the therapy on chronic non-atrophic gastritis(spleen-stomach qi deficiency syndrome)after Hp eradication.Methods: A total of 100 patients with negative Hp in the initial test of chronic non-atrophic gastritis were collected,and 100 patients with Hp positive to negative after treated with quadruple therapy for 2 weeks and then undergo 4 weeks of drug withdrawal.Collect symptoms,tongue and pulse conditions of HP-negative patients and patients who have turned negative after HP treatment before and after sterilization,classify TCM syndromes and statistic the law of distribution on those.SPSS21.0 statistical software be used to divided randomly into 2 groups for patients who were meets the standards of both the Hp positive to negative and the deficiency of spleen-stomach qi syndrome,and there were 32 cases of TCM and 32 cases of western medicine.The TCM group was taken medicine with Erbai Yangzheng Decoction,the another was taken medicine with Rebapide,assess the efficacy indicators after4 weeks.Results: 1.Research of the relationship between HP and its eradication treatment and the distribution of TCM syndrome types.There were 200 patients be taken into this project.Among them,2 patients who had HP positive and turned negative after bactericidal treatment were excluded because of concealing their medical history.Finally,100 patients were included in the Hp negative group,and 98 in the Hp positive to negative group.The statistical results showed that among the 100 patients in the Hp negative group,the largest number of case was the syndrome of liver-stomach incoordination with 33 cases.There are 9 cases of syndrome of dampness-heat of spleen-stomach,26 cases of deficiency of spleen-stomach qi,12 cases of mixed syndrome of cold and heat,8 cases of spleen-stomach cold deficiency,and 12 cases of deficiency of stomach Yin.Among the 98 patients in Hp positive to negative group,before eradication and treatment,there were 19 cases of syndrome of liver-stomach incoordination,36 cases of dampness-heat syndrome,and 23 cases of spleen-stomach weakness,5 cases of mixed cold and heat syndrome,and 5 cases belongs to spleen-stomach deficiency cold syndrome,the syndrome of stomach Yin deficiency has 10 cases.After sterilization by quadruple therapy,the number of cases of each syndrome type changed.The number of the above six syndromes became 11 cases,9 cases,64 cases,3 cases,5 cases and 6 cases in turn.Among the six TCM syndrome types,Hp negative patients accounted for the most in syndrome of liver-stomach incoordination,mixed cold and heat,spleen-stomach weakness and stomach Yin.Before the eradication treatment,the proportion of patients with HP positive to negative in the syndrome of dampness-heat in the spleen and stomach was the largest,and after the eradication treatment,the proportion of patients with negative Hp in the syndrome of Qi deficiency in the spleen and stomach was the largest.HP-positive patients account for the largest proportion;in the spleen-stomach weakness,patients whose HP turns negative account for the largest proportion.The test results show that P<0.01,suggesting that the distribution of the above three types of TCM syndromes has significant statistical significance(p﹤0.01).The specific difference is that the HP negative group and the HP negative group before sterilization have statistically significant differences in the distribution of the two syndromes of liver and stomach discord and spleen and stomach damp-heat(P<0.05),The discrepancy was statistically significant about the distribution of dampness-heat syndrome and spleen-stomach weakness syndrome before and after eradication treatment(P<0.05).The heterogeneity between Hp negative group and Hp positive to negative group after eradication treatment was statistically meaningful in TCM syndrome of liver-stomach disharmony,spleen-stomach weakness,and syndrome of mixed cold and heat(P<0.05).In the transformation of TCM syndromes before and after eradication treatment in the HP negative group.The statistical results showed that after the eradication treatment,the changes in the frequency of the syndrome and the frequency of the transformation from the syndrome of disharmony between liver and stomach to the syndrome of spleen and stomach qi deficiency were statistically significant after the eradication treatment(P < 0.001),the change of the syndrome and the frequency change of the spleen-stomach dampness-heat transforming into the syndrome of Qi deficiency of spleen and stomach were statistically significant(P < 0.05),and the transformation of frequency of patients with deficiency of stomach Yin syndrome into spleen-stomach weakness were statistically significant(P < 0.05).There was no statistical significance in the frequency of conversion in the rest of the other syndromes(P > 0.05).The above results indicate that the colonization and eradication treatment of Helicobacter pylori may be closely related to the liver-stomach discordance syndrome,spleen-stomach damp-heat syndrome,spleen-stomach qi deficiency syndrome,and cold-heat complex syndromes.Patients with negative initial HP screening often take liver-stomach discordance as the Its characteristic syndrome manifestations.Patients with HP from positive to negative are usually characterized by dampness-heat syndrome of spleen-stomach before eradication treatment and are usually characterized by spleen-stomach weakness syndrome after eradication treatment.Although the syndromes of mixed cold and heat were not the characteristic syndromes of Hp negative or the conversion of Hp from positive to negative after eradication treatment,the proportion of the syndromes was significantly different between the two groups.After Hp eradication treatment,some patients may experience the transformation of TCM syndrome type,among which,it is more common for patients with previous syndrome of disharmony between liver and stomach,syndrome of dampness-heat in spleen-stomach,and deficiency of stomach Yin to change to syndrome of qi deficiency of spleen-stomach.2.Study on the therapeutic effect of Erbai Yangzheng Decoction on chronic non-atrophic gastritis with spleen and stomach Qi deficiency syndrome in which HP turns negative.Effective rate: In the TCM group,1 case was cured,8 cases show an excellent effect,20 cases were effective,and there was 1 invalid case.The effective rate was 96.7% in total.In the western medicine group,there was 0 cases be cured,2 cases showed obvious effect,25 cases were effective,and 3 cases invalid.The total effective rate was 90%,and the distinction was significant in statistics(P < 0.05).The total score of symptoms of spleen and stomach qi deficiency: The TCM group and the western medicine group were compared.The differences between the two groups before and after treatment were compared respectively,the results were meaningful in statistics(P <0.001).Comparing the two groups after treatment in TCM symptom scores,the conclusion is that the difference was statistically significant(P < 0.001).Which suggest that there are significant effects for both the two group on improving the symptoms of spleen-stomach qi deficiency,and the curative effect of traditional Chinese medicine group was superior.The scores of the main symptoms of TCM: The two groups were compared before and after treatment respectively,the scores of all symptoms were different in statistics(P < 0.05);And the scores after treatment were compared between the two groups,results show that there were statistically significant differences in symptoms of abdominal distention and fullness and spiritlessness-fatigue(P < 0.05),while there was no statistical significance between the two groups in the symptoms of epigastric pain(P > 0.05).It is suggested that after treatment,the two groups have obvious improvement in gastric irritation,gastric pain,and spiritlessnes-fatigue.And the effect of TCM group was better in therapeutic efficacy of gastric distaste and fatiguethan that western medicine group.But there was no significant difference in statistics between the two groups in the curative effect of epigastric pain.Scores of various symptoms of TCM: Compared the two groups before and after treatment,the TCM group has statistically significant distinction in relieve anorexia,post-eating abdominal distension,early fullness,and loose stools(P<0.05),but there is no statistically significant difference in bowel difficulties.(P>0.05);in the western medicine group,there was statistically significant discrepancy in the improvement of appetite loss and abdominal distension after eating(P < 0.05),but there was no statistically significant difference in the treatment of early satiety,loose stool and difficult stool(P > 0.05).After treatment,the differences between the groups were statistically significant in the symptoms of loss of appetite,loose stools,and difficult bowel movements(P<0.05).There was no statistically significant difference between the groups in terms of post-eating abdominal distension and early satiety symptoms(P >0.05).The results indicated that both groups had obvious curative effect in anorexia,and the effect of TCM group was better than another;in the therapeutic effect of post-eating abdominal distension and early satiety,the two groups have curative effects and have the same curative effect;in loose stool,the TCM group had an effect while the western medicine group had no obvious effect in the treatment of difficult stool,and neither the TCM group nor the western medicine group has obvious improvement.Chronic gastritis symptom score: Within the group before and after treatment,there was a statistically significant difference between the two groups(P < 0.001);Compare the two groups after treatment,the diversity between the two groups was statistically significant(P <0.05).It is suggested that two groups can significantly improve the symptoms of chronic gastritis,and the curative effect of TCM group is better than that western medicine group.Conclusion: 1.HP and its eradication treatment are significantly related to the distribution of TCM syndrome types.The colonization and eradication treatment of Hp may be closely related to the TCM syndrome of liver-stomach discord,spleen-stomach damp-heat syndrome,spleen-stomach qi deficiency syndrome,and cold-heat complex syndromes.Patients with negative HP initial screening often have liver-stomach discordance as their characteristic syndrome.Patients with HP becoming negative often have spleen-stomach damp-heat as their characteristic syndrome before sterilization treatment.After the eradication treatment,patients with Hp from positive to negative are often characterized by the syndrome of spleen-stomach qi deficiency.Hp eradication therapy can cause the transformation of TCM syndrome type in some patients,among which,the transformation of syndrome type to spleen-stomach weakness is more common in patients with previous syndrome of liver-stomach disharmony and the syndrome of dampness-heat in spleen-stomach,and deficiency of stomach Yin.2.Erbai Yangzheng Decoction and Rebamipide Tablets are effective in the treatment of chronic non-atrophic gastritis(spleen and stomach Qi deficiency syndrome)in which HP turns negative,and Erbai Yangzheng Decoction is superior to the curative effect of improving TCM syndromes Rebapite film.