To Explore The Clinical Efficacy Of Cold Palsy Moxibustion With Ginger Based On Inflammatory Factors On Ankylosing Spondylitis

Objective:1.To observe the clinical efficacy and safety of cold palsy with ginger moxibustion for the treatment of kidney deficiency and cold type AS;2.To observe the changes of serum IL-6 and TNF-α in patients after treatment,and to initially explore the mechanism of action of cold palsy san isolated ginger moxibustion in the treatment of kidney deficiency and cold type of AS from the cytokine level,provide a theoretical basis for the clinical application of this therapy.Methods:Seventy-two patients with kidney deficiency and cold type AS who met the inclusion criteria in the rheumatology outpatient clinic of Yunnan Provincial Hospital of Traditional Chinese Medicine(Guanghua and Dianchi hospital areas)were selected and divided into36 cases in the control group and 36 cases in the treatment group using the random number table method.The patients in both groups had the same basic treatment,and the treatment group was treated with cold paralysis with ginger moxibustion,and the control group was treated with ginger moxibustion with ginger moxibustion,three times a week for two weeks as a course of treatment.The patients’ symptom scores,signs,TCM evidence points,inflammation indexes(ESR,CRP),inflammation factors(IL-6,TNF-α),TCM evidence efficacy,Western medicine disease efficacy,and changes in safety indexes were observed before and after treatment in both groups,so as to evaluate the efficacy and safety.Results:1.Symptom scores:After treatment,the spinal pain VAS scores,overall assessment(PGA)scores,somatic function index(BASFI)scores,and disease activity(BASDAI)scores in both groups were statistically significant when compared with those in the group before treatment(P<0.05);the treatment group was better than the control group when compared between the two groups(P<0.05).2.Comparison of physical signs: after treatment,finger-ground distance and Schober’s test were improved in both groups compared with before(P<0.05);compared between groups,there was a significant difference(P<0.05).After treatment,occipital wall distance and thoracic mobility were not significantly improved in both groups(P>0.05);there was no significant difference when comparing between groups(P>0.05).3.Chinese medicine evidence points: after treatment,the Chinese medicine evidence points in the treatment group decreased significantly compared with before(P<0.01),and also decreased in the control group(P<0.05);there was a significant difference between the groups(P<0.05).4.Inflammatory indexes: After treatment,ESR and CRP decreased significantly in the treatment group(P<0.05),and ESR and CRP did not improve significantly in the control group(P>0.05);there was a significant difference between groups(P<0.01).5.Inflammatory factors: after treatment,IL-6 and TNF-α decreased significantly in the treatment group compared with before(P<0.01),and IL-6 and TNF-α did not decrease significantly in the control group(P>0.05);compared between groups,there was a significant difference(P<0.01).6.Chinese medicine disease efficacy:After treatment,the total effective rate of the treatment group was 90.6%,and the total effective rate of the control group was 73.3%;the efficacy of the treatment group was better than that of the control group(P<0.05).7.Efficacy of Western medicine disease: after treatment,the attainment rate of ASAS20 was 84.4% in the treatment group and 60.0% in the control group,with significant difference(P<0.05).8.Comparison of safety indexes: there were no allergic and other adverse reactions in both groups with local medication;there was no significant difference between and within groups when comparing before and after treatment of blood routine,liver function,kidney function,and second stool routine + occult blood in both groups(P>0.05).Conclusion:1.Cold palsy san isolated ginger moxibustion can effectively improve patients’ clinical symptoms and signs,reduce ESR and CRP levels,and have significant efficacy on kidney deficiency and governor’s cold type AS.2.The mechanism of action of cold palsy san isolated ginger moxibustion in the treatment of AS may be related to the reduction of IL-6、TNF-α levels,but the specific mechanism needs to be further studied.3.There were no significant adverse effects of cold palsy with ginger moxibustion,which is worthy of clinical application.