Analysis Of Medication Regularity And Clinical Study Of The Treatment Of Diarrhea Diseases With Excessive Cold And Dampness Type Based On Data Mining

Objectives:In this study,through data mining,analysis of the medication regularity with excessive cold and dampness type,and then provided literature guidance and clinical medication basis for the treatment of people with the disease.And to explore the clinical efficacy of self made prescription of traditional Chinese medicine through clinical observation of 60 patients of diarrhea diseases with excessive cold and dampness type.Methods:1.Data Mining: This study collected ancient and relevant literature and search the“CNKI”literature database on the treatment of diarrhea diseases with excessive cold and dampness type.The case database was eatablished by entering drug composition into mrosoft excel 2010.Then,EXCLE 2010,SPSS Clementine(ver.18.0)and SPSS(ver.25.0)were adopted respectively for frequency analysis,association rules analysis,cluster analysis.Cluster analysis is carried out by Ochiai algorithm of binary variable data,one of the systematic clustering methods.2.Clinical observation: observation: This study collected 60 patients were randomly divided into a treatment group and a control group,with 30 cases in each group.The treatment group took self made prescription of traditional Chinese medicine,and the control group took Montmorillonite powder.Both groups were treated for 2 weeks.The clinical symptom scores were observed before treatment,after treatment respectively.SPSS25.0 software was used for statistical analysis,so as to observe the changes of clinical symptoms,TCM syndrome scores,effective rate,significant efficiency and recurrence rate of the two groups.Results: 1.Data Mining: In this study,a total of 70 prescriptions for the treatment of diarrhea diseases with excessive cold and dampness type were collected,involving 124 flavors of traditional Chinese medicine.The analysis showed that the top ten flavors of the drugs used in the treatment of diarrhea diseases with excessive cold and dampness type were poria cocos,rhizoma atractylodis magnolia officinalis,liquorices,rhizoma atractlylodis,zingibers rhizoma,alismatis thizoma,pinellia ternata,radix aucklandiae;The Chinese medicines with frequency >10 were classified,and the top two proportions were tonics and drugs for regulating qi flow.A tolal of 360drug-related items were obtained.The compatibility of Liquorice and rhizoma atractylodis macrocephalae has the highest degree of support,which is 57.97%.Most association rules are related to Pingwei Powder and Wuling Powder.Morever,7 medicine groups with relevance were extracted from the tree map generated by cluster analysis in total.2.Clinical observation results: Results:(1)The apparent efficiency of the treatment group was 63.33%,while that of the control group was13.33%,there was statistical significance in apparent efficiency between the two groups(P<0.01),and the treatment group was superior to the control group;the total effective rate of the treatment group was 96.67%,and the total effective rate of the control group was 86.67%,there was statistical significance in the total effective rate between the two groups(P<0.01).(2)There were significant statistical significance in the scores of symptoms and the total scores of symptoms between the two groups after treatment compared with those before treatment(P<0.01),and it is better after treatment than before.(3)After treatment,there were statistical significance between the two groups in the scores of number of stools,abdominal pain,inappetence,aversion to cold and the total scores of symptoms(P<0.01),and the treatment group was superior to the control group.(4)In the 2-week after treatment,the recurrence rate of the treatment group was 17.24%,while that of the control group was 40.00%,there was statistical difference between the two groups(P<0.05).(5)There were no adverse reactions in the two groups.