Analysis And Retrospective Study Of Medication Regularity Of Oral Traditional Chinese Medicine Combined With Fumigation And Washing In The Treatment Of Diabetic Peripheral Neuropathy

Purpose:Based on data mining technology,analyze the medication rules of oral traditional Chinese medicine and traditional Chinese medicine fumigation in the treatment of diabetic peripheral neuropathy in CNKI literature,verified the results with real-world case information,and discuss the real-world medication rules.Method:In the literature research,CNKI is used as the literature database to collect and count the Chinese literature and medicines that meet the standards,input to the traditional Chinese medicine inheritance computing platform to analyze the frequency,nature,taste,meridian and association rules of the medicines,summarize the laws of traditional Chinese medicine treatment.Results:1.Analysis of literature research(1)General information(1)Chinese Herbal oral literature: A total of 323 prescriptions were entered,including206 traditional Chinese medicines,and the total frequency of medication was 3577 times.(2)Chinese Herbal fumigation literature: A total of 274 prescriptions were entered,including 179 traditional Chinese medicines,and the total frequency of medication was 2671 times.(2)Analysis of frequency(1)Chinese Herbal oral literature: The top 6 most frequently used drugs are Astragalus,Angelica,Chuanxiong,Chixueteng,Dilong,and Salvia.(2)Chinese Herbal fumigation literature: The top 6 drugs with the most frequently used drugs are safflower,guizhi,chuanxiong,angelica,chicken blood vine,and astragalus.(3)Analysis of efficacy: Chinese Herbal oral literature and Chinese Herbal fumigation literature: A total of 18 categories of drugs were involved,and the top three in terms of efficacy frequency were the drugs for promoting blood circulation and removing blood stasis,tonic and heat-clearing drugs.(4)Analysis of meridian(1)Chinese Herbal oral literature and Chinese Herbal fumigation literature: A total of 12 meridians are involved,the top three in terms of meridian is Liver Meridian of Foot Jueyin is the most frequent,followed by the Spleen Meridian of Foot Taiyin and Heart Meridian of Hand Shaoyin.(5)Analysis of four natures and five flavors(1)Chinese Herbal oral literature: Middle and warm herbs were used most frequently,followed by cold herbs and flat herbs four natures.Among the five flavors,sweet flavors were used most frequently,followed by bitter and pungent flavors.(2)Chinese Herbal fumigation literature: Middle and warm herbs were used most frequently,followed by cold herbs and flat herbs four natures.Among the five flavors,sweet flavors were used most frequently,followed by bitter and pungent flavors.(6)Analysis of association rules(1)Chinese Herbal oral literature: A total of 10 traditional Chinese medicines are involved,with a total of 19 association rules,sorted by confidence,the top 10 are Angelica,Chixueteng→Astragalus,Chixueteng→Astragalus,Guizhi→Astragalus,Dilong→Astragalus,Peach Kernel→Safflower,Salvia → Astragalus,Chuanxiong → Astragalus,Achyranthes →Astragalus,Safflower → Astragalus,Angelica,Chuanxiong → Astragalus.(2)Chinese Herbal fumigation literature: A total of 5 traditional Chinese medicines are involved,and a total of 7 association rules,sorted by confidence,are Guizhi→Safflower,Chuanxiong→Safflower,Angelica→Safflower,Chixueteng→Safflower,Angelica→Chuanxiong,Safflower→Gui Branch,Angelica → Guizhi.2.Analysis of real world case data(1)General information(1)Case information: A total of 94 cases were collected,including 5 types of syndromes,and the duration of the disease included the first diagnosis to 30 years of onset.(2)Prescribing Information: A total of 94 prescriptions were collected,involving a total of 132 drugs.(2)Analysis of syndromes frequency: Liver-kidney deficiency syndrome occurred most frequently,31 times,accounting for 32.98% of the total frequency.(3)Analysis of syndrome type and disease course distribution: In cases with a course of less than 1 year,Yin Deficiency and Blood Stasis syndrome occurred most frequently,and Liver and Kidney Deficiency syndrome occurred most frequently in 1-9 years and 10-19 years,8 and 17 times.In the course of 20 years and above,the distribution of syndrome types was relatively average.(4)Analysis of medication rules: The 3 core drug combinations are Astragalus,Achyranthes,Dilong,Chuanxiong,Chishao;Astragalus,Chishao,Chenpi,Alisma,Plantago;Pueraria,Schisandra,Trichosanthin,Astragalus,Rehmannia.Conclusion:(1)Oral traditional Chinese medicine in the treatment of DPN mostly focuses on promoting blood circulation and removing blood stasis,nourishing Qi and blood.(2)Traditional Chinese medicine fumigation and washing in the treatment of DPN mainly focus on promoting blood circulation and removing blood stasis,expelling wind and removing dampness.(3)Through this study,it is concluded that blood stasis is the main pathogenesis of DPN,and Phlegm-dampness,Qi deficiency,Yin deficiency,and Liver and kidney deficiency are always around it.In terms of treatment,while promoting blood circulation and removing blood stasis,it takes time to take into account the treatment methods such as strengthening the spleen and eliminating dampness,nourishing Qi and nourishing Yin,and nourishing the Liver and kidney.