Study On Professor Ma Jian’s Medication Rules And Clinical Experience In The Treatment Of Diabetic Peripheral Neuropathy With Traditional Chinese Medicine

Objective:Using the Traditional Chinese Medicine Inheritance Computing System(V3.0),the core drugs of Professor Ma Jian in the treatment of diabetic peripheral neuropathy were obtained,and the syndrome differentiation thought and drug compatibility principle of Professor Ma Jian in the treatment of diabetic peripheral neuropathy were summarized.Methods:The medical records of patients with diabetic peripheral neuropathy treated in the outpatient department of Professor Ma Jian from January 2019 to May2022 were collected,and 110 cases meeting the inclusion and exclusion criteria were summarized.After unified and standardized processing of the data,The basic information,current situation,tongue,pulse and prescription of the patients were imported into the Excel sheet downloaded from the Traditional Chinese Medicine Inheritance Computing System(V3.0)for cluster analysis and frequency summary.Results:1.Among the 110 patients with DPN,66(60%)were male and 44(40%)were female.The age of onset was concentrated in 61-70 years old(48cases),accounting for 43.63% of the total number.2.The clinical symptoms of 110 patients were numbness of the lower limbs,fatigue,fear of cold in the lower limbs,pain in the lower limbs,dry mouth,numbness of the upper limbs,insomnia,thirst,constipation and blurred vision.3.There were 15 tongue patterns and 18 pulse patterns.The top two tongue images with high frequency were dark red tongue(100 times)and white tongue coating(75 times),accounting for 55.37% of the total tongue images.String slippery pulse(44 times)and string slippery number pulse(23 times)are high frequency pulse,accounting for 60.90 % of the total pulse frequency.4.A total of 113 Chinese herbs were used in 110 prescriptions,among which the top three were: Dried Ginger,Ramulus Cinnamomi,Radix Astragali.5.Analysis of 110 prescriptions showed that the top three of the four qi use frequency were : warm,cold and flat,accounting for 90.70 % of the total frequency;the top three frequently used five flavors are : sweet,bitter and spicy,accounting for 90.00 % of the total frequency;the frequency of meridian tropism greater than 500 times from high to low is : heart,liver,lung,spleen,kidney essence,stomach,accounting for 87.16 % of the total frequency.6.Among the 110 drug prescriptions,the top three drug efficacy were :tonifying deficiency 436 times(20.45 %),clearing heat 403 times(18.91 %),promoting blood circulation and removing blood stasis 378times(17.73 %).7.Using association rules to analyze the prescription rules,eight core drugs were obtained : coptis rhizoma,angelica sinensis,dried ginger,cinnamomum twig,peach kernel,safflower,asarum and astragalus membranaceus.8.Using k-means clustering analysis,7 core prescription drug combinations were obtained:(1)Dried Ginger,Herba Asari,Safflower,Chuanxiong,Radix Astragali,Ramulus Cinnamomi,Radix Paeoniae Rubra,Angelica sinensis;(2)Peach kernel,Radix Astragali,Angelica sinensis,Safflower,Rhizoma Coptidis,Poria,Radix Paeoniae Rubra,Dried Ginger;(3)Dried Ginger,Ramulus Cinnamomi,Radix Paeoniae Rubra,Radix Astragali,Herba Asari,Angelica sinensis,Peach kernel,Tetrapanax Papyriferus;(4)Peach kernel,Radix Astragali,Radix Paeoniae Rubra,Safflower,Rhizoma Coptidis,Poria,Angelica sinensis,Dried Ginger;(5)Safflower,Peach kernel,Angelica sinensis,Ramulus Cinnamomi,Chuanxiong,Herba Asari,Dried Ginger,Pberetima;(6)Rhizoma Coptidis,Dried Ginger,Ramulus Cinnamomi,Radix Astragali,Herba Asari,Safflower,Peach kernel,Red Yeast Rice;(7)Ramulus Cinnamomi,Herba Asari,Radix Astragali,Dried Ginger,Peach kernel,Radix Ophiopogonis,Rhizoma Coptidis,Rehmannia glutinosa.Conclusion:1.Professor Ma Jian’s frequent drugs for the treatment of diabetic peripheral neuropathy were coptis rhizoma,angelica sinensis,dried ginger,cinnamomum twig,peach kernel,safflower,asarum and astragalus membranaceus.2.Among the drugs of Professor Ma Jian for the treatment of diabetic peripheral neuropathy,the taste is mainly sweet,bitter and spicy,the properties are mainly warm,and the meridians of the drugs are mainly into the heart and liver meridians.3.Professor Ma Jian’s drugs for the treatment of diabetic peripheral neuropathy are mainly tonifying deficiency drugs,followed by heat-clearing drugs and drugs for promoting blood circulation and removing blood stasis.4.Professor Ma believes that the basic pathogenesis of diabetic peripheral neuropathy is deficiency of both qi and Yin,blood stasis of veins,phlegm dampness and blood stasis are the pathological products,and blood stasis runs through the whole process.5.Professor Ma Jian in the treatment of diabetic peripheral neuropathy in the process of starting from the whole,pay attention to reconcile the organs,the treatment of Yiqi Huatan,promoting blood circulation and removing blood stasis as the principle,syndrome differentiation and treatment,with the addition and subtraction.