Study On The Real World Medication Rule Of Traditional Chinese Medicine For Diabetic Peripheral Diabetic Peripheral Neuropathy Based On Data Mining

Purpose:To excavate the potential rules of traditional Chinese medicine in the treatment of diabetic peripheral neuropathy,this paper analyzed the medication of patients with diabetic peripheral neuropathy in the Thyroid Disease Diagnosis and Treatment Center of Hubei Provincial Hospital of Traditional Chinese Medicine/Guanggu Endocrinology Department by using the ancient and modern medical case cloud platform.Provided help for the clinical use of traditional Chinese medicine to treat diabetic peripheral neuropathy.Method:Collect 186 cases of diabetic peripheral neuropathy patients who were hospitalized in the Thyroid Disease Diagnosis and Treatment Center/Optics Valley Endocrinology Department of Hubei Provincial Hospital of Traditional Chinese Medicine from September 2019 to December 2021,and were treated with complete Chinese medicine prescriptions.Record these patient’s general information,clinical manifestations,certificates,and prescription drugs,and enter into the“Ancient and Modern Medical Case Cloud Platform” developed by the China Academy of Chinese Medical Sciences,and conduct data mining and analysis,and analyze the patient’s gender,age,tongue veins,frequency of medication,frequency of clinical manifestations,the frequency of the evidence type,the frequency of the evidence,the properties of the drug,and the relationship between the drug and the symptoms,etc.Results:1.Basic information: Gender statistics show that the ratio of men to women is about 1.51:1;the average age is 63.13±10.93 years,among which 50 to 69 years old is the high incidence age group,accounting for62.36% of the total number;the average course of the disease is11.78±7.14 years.2.Clinical symptoms: more frequent occurrence of clinical symptoms are limb numbness,thirst and drinking,blurred vision,fatigue,dizziness.3.Tongue pulse statistics: more frequent occurrences of tongue body are tongue red,light tongue,and dark red tongue;more frequent occurrences of tongue coating are thin coating,thin yellow coating,and white thin coating;more frequent occurrences of the pulse are string-like pulse,fine pulse,and fine and string-like pulse.4.Syndrome type and symptom factors: more frequent occurrences of syndrome type are syndrome of static blood blocking collaterals,syndrome of deficiency of both qi and yin,syndrome of blood stasis due to qi deficiency;evidence is blood stasis,qi deficiency,yin deficiency.5.Statistics on the use of Traditional Chinese medicine: A total of226 flavors of Traditional Chinese medicines were used,with a total frequency of 2630 times.26 flavors of Traditional Chinese medicines with a frequency of 20 times or more account for 54.7% of the total.The top ten of the total are Astragalus,Angelica,Poria,Red sage root,Reticulate millettia,Radix rehmanniae recen,Liriope sticata,Peach Kernel,Yam,and Ligusticum wallichii.6.Statistics of traditional Chinese medicine attributes: The results of the four qi from high to low are flat,warm,cold,slightly cold,micro-warm,cool,big heat,hot,and cold.The statistics of the five flavors results are sweet,bitter,hot,slightly bitter,acidic,light,salty,astringent,and slightly sweet.The results of the drug’s cannel tropism are liver meridian,lung meridian,spleen meridian,kidney meridian,heart meridian,stomach meridian,large intestine meridian,bladder meridian,bile meridian,pericardial meridian,small intestine meridian,and sanjiao meridian;the most common chinese medicine drugs are tonic drugs,blood stasis drugs,and antipyretic drugs,which are 833 times,460 times,and 443 times,respectively.7.Drug-to-frequency statistics: There are 34 pairs of drug pairs with a frequency of 20 or more.The top five of total are astragalus and angelica,astragalus and poria,astragalus and red sage root,angelica and poria,astragalus and radix rehmanniae recen.8.Cluster analysis: The correlation analysis of drugs and drugs obtained 5 categories.The first category: poria,astragalus,angelica;the second category: radix rehmanniae recen,red sage root,reticulate millettia,caulis lonicerae;the third category: yam,sealwort,chinese taxillus herb,white atractylodes rhizome,beach silvertop root,radix pseudostellariae,liriope sticata;the 4th category : peach kernel,safflower,ligusticum wallichii,cassia twig,red peony;the 5th category: bidentate achyranthes,arrowroot,dipsacus root,radix scrophulariae,rhizoma anemarrhenae,reed root.The correlation analysis of symptoms and drugs obtained 15 related rules,involving 5 symptoms and 9 flavors of traditional Chinese medicine.ConclusionThrough data mining,it is concluded that the most common type of DPN is blood blocking collaterals,followed by syndrome of deficiency of both qi and yin,syndrome of blood stasis due to qi deficiency,sputum stasis mutual resistance certificate,yang deficiency cold coagulation evidence.The disease mechanism is mostly blood stasis,qi deficiency and yin deficiency.The treatment methods are mostly supplementing qi and nourishing yin,promoting blood circulation to dispel blood stasis,clearing away heat and promoting diuresis,supplemented by tonifing the liver and kidneys,dispelling pathogenic wind and eliminating phlegm.Types of drugs are based on tonic drugs,blood-activating and stasis-reducing drugs and heat-clearing wet medicine,supplemented with water-infiltrating drugs and rheumatic drugs.The falvors of drugs are sweet and flat.The drugs are mainly based on the liver meridian,the lung meridian,the spleen meridian,supplemented by the kidney meridian and the heart meridian.Through the cluster analysis of the association between drugs,5 high-frequency drugs were obtained,which can help in the treatment of DPN in traditional Chinese medicine.