A Study Based On Data Mining Of Rule Of Syndrome And Treatment Of Ulcerative Colitis

Objective: This study takes ulcerative colitis as the research object,takes the characteristic treatment of traditional Chinese medicine as the starting point,and combines modern medical statistical methods such as frequency,clustering,factor,and correlation analysis to mine and study the relevant medical records.Summarize and integrate the epidemiological characteristics,symptoms and syndrome distribution of ulcerative colitis,and explore the prescription and compatibility laws of various doctors,in order to provide reference for clinical treatment and new drug research and development.Methods: Retrieve the relevant documents on the treatment of ulcerative colitis by traditional Chinese medicine in the past five years from CNKI,Wanfang data,and VIP,and extract the basic information,symptoms and signs,pathogenesis and syndromes,prescription and medication of patients from the medical records,and then establish the corresponding database and conduct standardized treatment.SPSS Modeler 18.0,SPSS Statistics 23.0 and other medical statistical software were used to process and analyze the databases,and to explore the rule of syndrome and treatment of ulcerative colitis treated by traditional Chinese medicine.Results: A total of 124 articles were included,including 150 medical records,356 oral prescriptions of traditional Chinese medicine and 45 enema prescriptions of traditional Chinese medicine.The mining results obtained by data analysis are as follows:(1)Basic information: A total of 150 patients with UC were included,including 88 male patients and 62 female patients,with the gender ratio of 58.67% and 41.33%respectively;As far as the age distribution of patients is concerned,people of all ages may suffer from UC,with the majority of young and middle-aged people: 28 cases aged 21 to30,39 cases aged 31 to 40,and 39 cases aged 41 to 50;In terms of the distribution of diagnosis types,the majority of patients were active(96 cases,23.41%),moderate(25cases,6.10%),rectal(32 cases,7.80%),and colon(27 cases,6.59%).(2)Distribution law of symptoms and signs: high-frequency symptoms include diarrhea(accounting for about 77.99%),mucopurulent bloody stool(76.90%),abdominal pain(54.08%),fatigue and fatigue(39.95%),lack of appetite(28.80%),etc;High frequency tongue images include red tongue(67.25%),light tongue(46.38%),dark tongue(22.90%),dentate tongue(18.55%),fat tongue(10.43%),etc;High-frequency fur images include greasy fur(53.46%),yellow fur(49.03%),white fur(44.04%),thin fur(32.96%),thick fur(11.63%),etc;High-frequency pulse images include fine pulse(49.15%),chord pulse(44.63%),slippery pulse(32.49%),sinking pulse(23.76%),number pulse(17.80%),etc.(3)Distribution of syndromes: high-frequency syndromes include damp-heat of large intestine(41.23%),weakness of spleen and stomach(20.61%),deficiency of both spleen and kidney(16.43%),dampness accumulation of spleen deficiency(11.14%),strong liver and weak spleen(11.14%),etc.(4)Drug frequency analysis: 266 kinds were involved,with a total frequency of 5585 times.High-frequency oral drugs include: Atractylodes macrocephala(74.72%),Paeonia lactiflora(56.74%),Coptis chinensis(53.65%),Coix lacryi seed(50.84%),Muxiang(48.88%),etc.,of which the deficiency drugs(26.80%)dominate;High-frequency enema drugs include: Phellodendron amurense(53.33%),Sanguisorba officinalis(51.11%),Sophora flavescens(48.89%),Baiji(46.67%),and Panax notoginseng(33.33%),among which antipyretic drugs(36.57%)dominate.(5)Drug cluster analysis: oral drugs can be divided into 6 categories,C1: Atractylodes macrocephala,Codonopsis pilosula,Poria cocos;C2: Paeonia lactiflora,Radix Aucklandiae,Rhizoma Coptidis;C3: Coix seed;C4: Sanguisorba officinalis;C5: licorice and astragalus;C6: roasted licorice,Chinese yam,orange peel,scutellaria,angelica,dried ginger,Patrinia villosa,agrimony,panax notoginseng,Pulsatilla,phellodendron,cortex fraxini,parsnip,etc.Enema drugs can be divided into 7 categories,C1: Platycladus orientalis leaves,sophora japonica,palm,and rubia;C2: catechu;C3: dandelion,purslane,scutellaria baicalensis;C4: Radix Astragali,Radix Angelicae,Cortex Phellodendri,Radix Notoginseng and Sophora flavescens;C5: Indigo Naturalis,Pulsatilla,Herba Agrimoniae,Coix Seed,Cortex Fraxini,Radix Glycyrrhizae,Rhizoma Coptidis,Radix Paeoniae Alba,Radix Ulmus;C6: Chinese gallnut;C7: bezoar,pearl,etc.(6)Drug association analysis: According to the drug association analysis results,the high-frequency associated drugs in oral drugs include: Atractylodes macrocephala-cortex citri,Atractylodes macrocephala-amomum villosum-codonopsis pilosula,Atractylodes macrocephala-fangfeng-cassia-coix seed,Atractylodes macrocephala-cortex citri-cassia-coptis chinensis-paeonia lactiflora,etc;High-frequency associated drugs in enema drugs include: Sophora flavescens-Radix Notoginseng,Coptis chinensis-Radix Glycyrrhizae-Rhizoma Angelicae,Cortex Phellodendri-Radix Glycyrrhizae-Rhizoma Coptidis-Rhizoma Angelicae,Sophora flavescens-Radix Notoginseng-Rhizoma Angelicae-Cortex Phellodendri,etc.Conclusion:(1)Epidemiological characteristics of UC: There is no significant gender difference in the incidence of UC,and the minor deviation may be related to lifestyle and eating habits;The disease can occur at all ages,with young and middle-aged people as the main population;In pathological stage,the active stage is more than the remission stage,the degree of disease is mostly moderate,and the lesions are mostly in rectum and colon.(2)Symptomological characteristics: The common symptoms of UC patients include diarrhea,mucopurulent bloody stool,abdominal pain,mental fatigue,lack of food and anorexia,etc;Typical tongue features include red tongue,light tongue,dark tongue,and dentate tongue;Typical fur appearance includes greasy,yellow,white and thin fur;Typical pulse manifestations include fine pulse,stringed pulse,slippery pulse,sinking pulse,etc.The clinical manifestations of this disease are complicated,and the tongue,pulse,and fur images should be taken into consideration in clinical diagnosis,and should be carefully identified.(3)Distribution of syndromes: The common syndromes of UC patients include damp-heat syndrome of large intestine,spleen and stomach weakness syndrome,spleen and kidney deficiency syndrome,spleen deficiency and dampness accumulation syndrome,liver strength and spleen weakness syndrome,etc.Among them,large intestine damp-heat syndrome and spleen and stomach weakness syndrome are the most common,suggesting that UC is often based on the weakness of the body,and damp-heat turbid poison is the standard.It should be noted that there are many symptoms of UC,and it is necessary to know how to change in clinical syndrome differentiation.(4)Core drug law: according to the drug frequency analysis results,commonly used oral drugs include: atractylodes macrocephala,paeonia lactiflora,coptis chinensis,coix seed,cassia,etc;Commonly used enema drugs include: Cortex Phellodendri,Sanguisorba officinalis,Sophora flavescens,Rhizoma leucorrhizae,Panax notoginseng,etc.The properties of the medicine are mainly warm,cold and slightly cold,with bitter and sweet taste.It can return to the spleen,stomach,lung and large intestine.The clinical prescription should be based on bitter cold medicine and bitter warm medicine,which should be increased or decreased according to the symptoms.(5)Medication thinking: according to the results of drug cluster analysis,the basic medication thinking of oral drugs is: mainly to replenish qi,supplemented by clearing heat and removing dampness,and also to treat according to syndrome differentiation or symptomatic treatment;The basic idea of using enema drugs is: mainly to stop bleeding and generate muscle,supplemented by clearing heat,drying dampness and detoxicating,and symptomatic treatment.Strive to be mixed to the best of your abilities.(6)Law of core drug pairs: according to the results of drug association analysis,common drug pairs of oral drugs include: Atractylodes macrocephala-tangerine peel,Atractylodes macrocephala-tuckahoe,Atractylodes macrocephala-amomum villosum,etc;Commonly used drug pairs of enema drugs include: Sophora flavescens-Panax notoginseng,Sanguisorba officinalis-Agrimonia,Coptis chinensis-Pulsatilla,etc.It is necessary to pay attention to the compatibility relationship between drugs and give full play to their mutual synergy when clinical prescription is used.