Observation On The Treatment Of Acute Attack Of Bronchial Asthma (Heat Asthma Syndrome) And Its Effect On Inflammatory Factors

Objective: This study studied the clinical therapeutic effect of "heat for cold,dryness for moist" in the treatment of bronchial asthma during acute attack(heat asthma),evaluated the safety and clinical efficacy,and provided new ideas and countermeasures for the treatment of bronchial asthma during acute attack(heat asthma).Methods: 100 patients who fulfilled the criteria for inclusion were completely at random assigned to one of two groups: control or treatment.Each group comprised 50 patients.The control group received standard normal westernized therapy,whereas the treatment group was medicated with traditional Chinese medicine based on the principle of "heat is cold,dry is moist".The duration of therapy is 10 days.After receiving therapy,observe and compare the changes of symptoms and signs,the improvement of neutrophil to lymphocyte ratio(NLR),eosinophil to lymphocyte ratio(ELR),HIF-1α,VEGF,TGF-β1,Creactive protein,lung function,symptom relief time and ACT(asthma control test score)of the two groups before and after therapy.Results:1.Clinical effectiveness: Following therapy,both groups exhibited improvement,but the treatment group’s therapeutic impact outperformed that of the comparison group.(P<0.05).2.Some indicators of blood routine tests,C-reactive protein,were found after treatment dramatically reduced in the two groups,treatment group’s reduction is superior to the control(P<0.05).3.Following therapy,the ACT.With substantial statistical significance,the scores in the two groups were substantially higher when compared to the pre-treatment group.(P <0.05);When contrasted with that of the control group,the treatment group’s ACT was substantially greater.4.Both sets of patients demonstrated substantially lower levels of shortness of breath,cough,expectoration,diaphragm and fullness of thorax,sensations of being short of breath,and overall assessment.(P<0.05).Besides that,the effects of the therapy group on wheezing,expectoration,cough,chest,diaphragm,wheezing,and total score were substantially better than controls.5.Both groups had infinitely better lung function metrics.The outcomes were noticeably better than pre-treatment(P<0.05).The therapy group’s impact on the pulmonary function index was notably surpassed that of the control group when contrasted to the latter.(P < 0.05).6.The traditional Chinese medicine treatment of "hot people are cold,dry people are moist" may play a certain role in the process of acute asthma attack.Conclusion: The prescription of " Treating heat syndrome with cold methods and treating dryness syndrome with wet methods " has a good clinical effect in improving cough,expectoration and wheezing symptoms of asthma patients.Pulmonary function was obviously enhanced in comparison with the control group.The ACT score was substantially healthier than it had previously been.The level of ELR and NLR HIF-1αand VEGF and TGF-β1inflammatory factors has a significant decrease compared with that before the treatment.It can help alleviate acute asthma symptoms in a quicker manner,enhance overall control,as well as is safe,demonstrating the worth of conventional medication.