Exploring The Efficacy Mechanism Of The Method Of Tonifying The Kidney And Resolving Phlegm In The Treatment Of PCOS Based On Chronic Inflammatory Factors

Objective:To observe the therapeutic effect of the method of tonifying the kidney and resolving phlegm on the polycystic ovary syndrome with kidney deficiency and phlegm-dampness,and to explore the efficacy mechanism of the method of tonifying the kidney and resolving phlegm in the treatment of PCOS patients by detecting the level of chronic inflammatory factors.Methods:Seventy-two cases of PCOS with kidney deficiency and phlegm-dampness were selected from the Reproduction Center of Shandong Provincial Hospital,and were divided into the experimental group(Kidney Tonic and Phlegm Reduction Plus+Yusiyue)and the control group(Yusiyue)according to the randomized number table method.luteinizing hormone/folliculopoietin(LH/FSH),folliculopoietin(FSH),testosterone(T),estradiol(E2),prolactin(PRL),free testosterone(FT),17 α-hydroxyprogesterone(17α-OHP),sex hormone binding globulin(SHBG),tumor necrosis factor(TNF-α),interleukin-6(IL-6),fasting blood glucose(FPG),fasting insulin(FINS),HOMA-IR,acne score,hirsutism score,TCM evidence score,sinus follicle count,total efficacy,and change in follow-up menstrual cycle.Results:1.there was no statistically significant(P>0.05)comparison between the general information of patients in the two groups,which could be compared.2.after treatment of BMI in both groups,the difference between the groups was statistically significant(P<0.05),and after treatment of WHR in both groups,there was no statistical significance(P>0.05)for comparison within and between the groups.3.the differences were not statistically significant when comparing acne and hirsutism between the two groups after treatment(P>0.05);the differences were statistically significant when comparing acne within the two treatment groups(P<0.05),while the differences were not statistically significant when comparing hirsutism within the two treatment groups(P>0.05).4.LH,LH/FSH and T were statistically significant(P<0.05)when compared between the two groups after treatment,and the difference was significant(P<0.01)when compared within the group;FSH,PRL and E2 were compared within and between the two groups before and after treatment,and the results showed no difference(P>0.05).5.intra-group differences in FT and SHBG before and after treatment in both groups were significant(P<0.01),and intra-group differences in FT and SHBG after treatment were statistically significant(P<0.05).intra-and inter-group comparisons of 17α-OHP in both groups showed no differences(P>0.05).6.there was a significant difference in the comparison of TNF-α and IL-6within the group after treatment(P<0.01),and the comparison of TNF-α and IL-6 between the two groups after treatment(P<0.05).7.intra-group and inter-group comparison of FPG before and after treatment in both groups showed no difference(P>0.05),and inter-group comparison of FINS and HOMA-IR after treatment in both groups(P<0.05)was statistically significant,and intra-group comparison of FINS and HOMA-IR before and after treatment in both groups(P<0.01)was significantly different.8.the AFC was not statistically significant in both inter-group and intra-group comparisons after treatment.9.Comparison of TCM syndrome points: the difference between the two groups in total TCM syndrome points after treatment was significant(P<0.01),the difference between the groups in primary and secondary syndrome points after treatment was statistically significant(P<0.05),and the difference between the two groups in total,primary and secondary syndrome points before and after treatment was significant(P<0.01).10.Comprehensive efficacy determination: the total effective rate of the experimental group and the control group were 91.4% and 68.6%,respectively,and the difference in comprehensive efficacy between the two groups was statistically significant by chi-square test(P < 0.05).11.menstrual cycle: after treatment,the difference between the two groups was statistically significant(P < 0.01)and between the groups(P <0.05);3 months after the end of treatment,the comparison of menstrual cycle between the groups was statistically significant(P < 0.05).12.The effective rates of the follow-up menstrual cycles in the experimental group and the control group were 91.4% and 62.9%,respectively,and the apparent healing rates were 68.6% and 42.9%,respectively,by Fisher’s exact test(P<0.05),indicating that the effective rates of the experimental group were higher than those of the control group.Conclusion:(1)Nourishing the kidney and resolving phlegm plus and minus formula combined with Usiyue can significantly alleviate the TCM symptom scores and clinical symptoms of acne in PCOS patients with kidney deficiency,phlegm and dampness.(2)Nourishing the Kidney and resolving phlegm plus and minus formula combined with Usiyue can effectively reduce LH,LH/FSH,T and FT secretion and up-regulate SHBG level in PCOS patients,which can overall regulate the functional status of HPO axis in patients with kidney deficiency,phlegm and dampness PCOS.(3)The combination of Kidney Tonic and Phlegm-Completing Plus and Minimizing Formula with Yousiyue can effectively reduce the levels of TNF-α and IL-6 inflammatory factors in PCOS patients with kidney deficiency and phlegm-dampness,and reduce the chronic inflammatory status of the organism in PCOS patients.(4)The efficacy of the combined drug group was significant compared with that of the Usiyue group alone,which is worthy of further promotion in clinical work.