Clinical Observation On The Treatment Of Early To Mid-Stage Knee Osteoarthritis Of Qi Stagnation And Blood Stasis Type By Combining Liver Draining And Eliminating Stasis Formula With Acupuncture

Objective: The purpose of this clinical observation is to verify the clinical effectiveness and safety of the treatment of early to mid-stage knee osteoarthritis of the qi stagnation and blood stasis type based on the use of the combination of the liver dredging and blood stasis formula with acupuncture to reduce knee pain,improve joint mobility and Chinese medicine symptoms,and to determine the value of its clinical application.Methods: By collecting patients who visited our inpatient and outpatient departments between December 2021 and December 2022,60 patients with early to mid-stage knee osteoarthritis with qi stagnation and blood stasis who met the inclusion criteria were screened and divided into a control group of 30 patients and an observation group of 30 patients according to simple random assignment.30 patients in the control group were given Celecoxib capsules orally + basic treatment(health education and functional exercise),and 30 patients in the observation group were given the formula to remove blood stasis from the liver internally + acupuncture + basic treatment(health education and functional exercise).In the control group,30 patients were given Celecoxib capsules orally + basic treatment(health education and functional exercise),and in the observation group,30 patients were given the formula to remove blood stasis in liver internally + acupuncture + basic treatment(health education and functional exercise)for 2 weeks.The VAS pain scores,WOMAC scores,TCM symptom scores and adverse reactions of patients in both groups were observed before and after 2 weeks of treatment,and the data were comprehensively evaluated and analyzed by using SPSS27.0.Results: A total of 60 patients were selected for this study,and 1case was excluded from the control group during the treatment process,resulting in a total of 59 cases(29 cases in the control group and 30 cases in the observation group)included in the analysis of the results.The general information(gender,age,disease location,disease duration,stage)of the patients between the two groups was compared at P > 0.05,and the differences were not statistically significant and comparable.The differences between the two groups before treatment(VAS score,WOMAC score and TCM symptom score)were not statistically significant(P > 0.05)and were comparable.The comparative analysis between and within the two groups after treatment was as follows.1.VAS pain score:(1)Within-group comparison: VAS scores in both groups were significantly lower after treatment compared with those before treatment,and the difference was significant(P < 0.01).(2)Comparison between groups: The difference in VAS scores between the two groups after treatment(P < 0.05)was statistically significant,indicating that the observation group was better than the control group in terms of pain relief in both groups.2.WOMAC score:(1)Intra-group comparison: The pain,stiffness,daily activity items and total scores of both groups decreased after treatment compared with the same group before treatment,and the statistical analysis showed significant differences(P < 0.01).(2)Inter-group comparison: After treatment,the WOMAC scores and total scores of the two groups were compared and analyzed at P < 0.01,with significant differences,and the observation group was significantly better than the control group.3.TCM syndrome score:(1)Intra-group comparison: After treatment,both groups showed a significant reduction in intrinsic TCM symptom scores compared with those before treatment,and the difference was significant by analysis(P < 0.01),indicating that both treatment regimens could achieve significant efficacy.(2)Inter-group comparison: The difference between the two groups after treatment was significant at P < 0.01,and it was found that the observation group was significantly better than the control group in both treatment regimens.4.The total efficacy of the disease was compared: the total effective rate of the control group was 89.00% after statistical analysis,while the total effective rate of the observation group was 96.66%,and the difference was statistically significant by rank sum test,P=0.031<0.05.5.The total efficacy of TCM symptoms was compared: the total effective rate of the control group was 79.31%,and the total effective rate of the observation group was 96.66%,and the difference was statistically significant by rank sum test,P < 0.01.Conclusion(s): 1.For the treatment of early to mid-stage knee osteoarthritis with qi stagnation and blood stasis,the combination of internal administration of the formula to remove blood stasis and external acupuncture can reduce the symptoms of knee pain and improve the function of movement,thus improving the quality of patients’ daily life,and the clinical efficacy is better than that of oral administration of Western medicine alone.2.During this trial,none of the patients included in the treatment had any significant adverse reactions or related complications during the treatment period,indicating that the combination of liver dredging and elimination of blood stasis formula with acupuncture for the treatment of KOA is safe and worthy of clinical promotion.