| Objective: To observe the clinical effect of Shuangshenyixin Decoction on ejection fraction preserving heart failure(qi deficiency and blood stasis)and its influence on myocardial energy metabolism,and to discuss its safety and provide new ideas and reference for the treatment of ejection fraction preserving heart failure.Methods: In this study,68 patients with ejection fraction retention heart failure(Qi deficiency and blood stasis syndrome)were selected from the outpatient department of cardiovascular disease of the First Affiliated Hospital of the Heilongjiang University of Chinese Medicine.The random number table method was adopted in the study,The patients were randomly divided into a control group and an experimental group with 34 cases,respectively.The control group was treated with conventional western medicine treatment,while the experimental group was provided with Shuangshenyixin decoction combined with Western medicine treatment,which the observation period was 28 days.Moreover,the TCM syndrome score of the patients was observed and recorded,and the changes in echocardiography(E/e′,E/A,LAVI value)and MEE,as well as the improvement of 6MWT,plasma NT-pro BNP and quality of life scale KCCQ were measured.Results: This study patients were divided into control group(34 cases)(shedding 2 cases),and experimental group(34 cases)(shedding 1 case).The obtained data of the two groups were comparable.1.The comparison of curative effect of TCM symptom scores: Curative effect of TCM symptom scores after treatment of the control group and the experimental group decreased compared with before treatment(P<0.05);The experimental group decreased more significantly(P<0.05),and the improvement rate of total effective rate was better than that in the control group(P<0.05).2.The comparison of 6MWT: After treatment,the walking distance of the control group and experimental group was longer than that before treatment,and the walking distance of the experimental group was better than that of the control group(P<0.01).3.The comparison of echocardiography(E/e′,E/A,LAVI,MEE): The values of E/e′,LAVI and MEE after treatment of the control group and the experimental group decreased compared with before treatment,and the decreased amplitude of the experimental group was more significant than that of the control group(P<0.05).Additionally,the E/A value after treatment of the control group and the experimental group was higher than that before treatment,and the increased amplitude of the experimental group was significantly better than that of the control group(P<0.05).4.The comparison of NT-pro BNP concentration: the control group and experimental group after treatment,NT-pro BNP concentration compared to the two groups before the treatment was decreased,the decrease of the experimental group was more significant than the control group(P<0.01).5.The comparison of KCCQ scores: KCCQ scores after treatment of the control group and experimental group were improved compared with the two groups before treatment,and the improvement of the experimental group was more significant than the control group(P<0.05).Conclusion:1.Shuangshenyixin Decoction can improve the ejection fraction to preserve the symptoms of heart failure and TCM syndroms in patients with heart failure(Qi deficiency and blood stasis syndrome),prolong the walking distance of 6MWT,reduce the level of NT-pro BNP in patients,and improve the KCCQ score.2.Shuangshenyixin Decoction can improve ejection fraction and retain echocardiogram E/A value in patients with heart failure(Qi deficiency and blood stasis syndrome),and reduce echocardiogram E/e′,LAVI and MEE values. |
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