| Objective:The aim of this study is to systematically evaluate the clinical efficacy and safety of auricular therapy in the treatment of post-stroke depression through Meta-analysis and data mining techniques,and to summarize the rules of auricular therapy in order to provide an evidence-based basis for clinical practice.Methods:A computerized search of the literature on auricular therapy for post-stroke depression was conducted in seven databases,including the China National Knowledge Infrastructure(CNKI),Wan–Fang Database,Chinese Scientific Journal Database(VIP database),Chinese Biomedical Literature Database(CBM),Pub Med,Excerpt Medica Database(EMBASE)and Cochrane Central Register of Controlled Trials(CENTRAL),since their establishment until February 2,2023.The studies that met the inclusion criteria were extracted and evaluated for quality,and statistical analyses were performed using Rev Man 5.3,Stata 16.0,SPSS Statistics 26.0,and SPSS Modeler 18.1.Results:The study included 28 publications,30 randomized controlled trials,a total of 2314 patients,28 prescriptions,14 acupuncture points,and a total frequency of 153.Meta-analysis results showed that: in terms of clinical efficacy,auricular therapy for post-stroke depression was significantly better than western medicine in terms of improvement in HAMD score(MD=-3.17,95%CI=[-3.95,-2.39]),SDS score(MD=-7.15,95%CI=[-13.49,-0.82])and overall effectiveness(RR=1.14,95%CI=[1.10,1.19])(P <0.05);subgroup analysis based on different interventions showed that auricular therapy alone(MD=-2.92,95%CI=[-5.20,-0.65]),auricular therapy combined with western medicine(MD=-2.69,95%CI=[-3.40,-1.97]),and auricular therapy combined with non-western medicine(MD=-3.68,95%CI=[-5.38,-1.97])were significantly better than western medication in improving HAMD scores(P < 0.05).In terms of safety,auricular therapy for post-stroke depression was significantly lower than western medication in terms of TESS scores(MD=-7.25,95%CI=[-13.30,-1.21])and incidence of adverse events(RR=0.37,95%CI=[0.22,0.61])(P < 0.05).The results of data mining showed that: the frequency of auricular point was from high to low: auricular nail,opposite ear screen,triangular fossa,opposite ear chakra;the frequency of auricular acupuncture points was from high to low: shenmen,heart,liver,kidney,subcortical,sympathetic,spleen,endocrine,brainstem,marginal middle,occipital,pancreatic-biliary,triple jiao,stomach;the types of auricular therapy involved both auricular acupressure and auricular acupuncture therapy,and the auricular acupressure method was the main method;cluster analysis yielded three major categories The ear acupuncture points were C1: liver,kidney,heart,and brainstem;C2: sympathetic,endocrine,and margin-medium;C3: subcortical,shinmen,occipital,and spleen;association analysis revealed that the highest support was for shinmen and heart and shinmen and liver;the highest confidence was for subcortical and shinmen,subcortical,liver,and shinmen,subcortical,heart,and shinmen,kidney,liver,shinmen,kidney,liver,heart,and shinmen,and kidney,heart,and Shen Men and Liver.Conclusion:1.The efficacy of auricular therapy(including auricular therapy alone,auricular therapy combined with non-western medicine,and auricular therapy combined with western medicine)in the treatment of post-stroke depression is significantly better than that of western medicine alone.2.Auricular therapy has fewer side effects and is safer than Western medicine.3.The auricular point used in the treatment of post-stroke depression are mainly the auricular nail,the para-auricular screen and the triangular fossa.The auricular acupuncture points used more frequently are Shen Men,Heart,Liver,Kidney,Subcortical,Sympathetic and Spleen.The main types of auricular therapy is auricular acupressure.4.Auricular therapy is often used to treat post-stroke depression by using visceral points and other points that regulate the neuroendocrine system,with the core prescriptions being Shen Men,Subcortical,Heart,Liver and Kidney. |
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