| Objective:Literature research section:Summarize,summarize,and analyze the current clinical research status of traditional Chinese medicine external treatment for rosacea,providing theoretical basis for future clinical treatment and scientific research.Clinical research section:To provide evidence-based medical evidence for the clinical efficacy and safety of cold compress of Liangxue Zhiyang Tang in the treatment of rosacea,and to provide data support for the future application of cold wet compress of traditional Chinese medicine decoction in the treatment of rosacea.Methods:Literature research section:Computer retrieval of China National Knowledge Infrastructure(CNKI),Chongqing VIP Database(VIP),and Wanfang Data Knowledge Service Platform(WF),conducted from January 1,2000 to November 1,2022.Conduct an advanced search on the topic of "rosacea" or "rosacea",and then set "traditional Chinese medicine" as the full-text search term to conduct a secondary search on the above search results.Select clinical research literature that meets the standards and uses traditional Chinese medicine as an intervention method,including randomized controlled trials(RCTs),non randomized controlled trials(NRCCTs),and uncontrolled case series.Enter all literature information into Microsoft Excel to establish a database for unified management.Analysis content:publication time,research type,RCT methodology quality evaluation,rosacea classification,intervention measures,intervention time,traditional Chinese medicine syndrome types,implementation sites of bloodletting,fire needle and acupuncture,frequency of traditional Chinese medicine taste.The RCT methodology quality assessment was conducted using the Risk Of Bias(ROB)tool recommended by Revman5.4 software.Two researchers will conduct data extraction and RCT methodology quality assessment separately.When there is disagreement,negotiations can be conducted or third-party assistance can be sought.Clinical research section:A randomized controlled trial was used to conduct a Exploratory research.Recruit 60 patients with erythematous telangiectasia or papulopustular rosacea,and randomly allocate them to the control group and experimental group using a random number table method,with 30 patients in each group,and allocate them in envelopes for concealment.Experimental group:cold compress with Liangxue Zhiyang Tang for facial treatment,control group:placebo cold compress for facial treatment,and basic treatment.Both groups received LED yellow light treatment.Observe the clinical symptom score,Visa red zone score,RosaQoL,GAD-2,and PHQ-2 depression screening scales.The course of treatment is 14 days,and evaluation is conducted before treatment,on the 7th day of treatment,and on the 14th day of treatment.Results:Literature research section:This study ultimately included 80 clinical research articles on the treatment of rosacea with external treatment of traditional Chinese medicine for analysis.Since 2016,the number of clinical studies on the treatment of rosacea with traditional Chinese medicine external treatment has rapidly increased.Among 80 articles,51 were randomized controlled trials(RCTs),6 were non randomized controlled trials,and 23 were case series.The methodological quality of RCT is average,with 48 articles failing to disclose the concealment of randomized protocols.All RCT studies did not blind the performer and subjects,and only 2 articles blinded the evaluators.The research intervention time was concentrated from 4 weeks to February,reaching 53 articles(66.25%).There are a total of 26 literature related to traditional Chinese medicine syndromes,of which the lung stomach heat syndrome is the most common,accounting for 14.The top five most frequently used external treatment methods of traditional Chinese medicine were bleeding 29,soaking 22,fire needle 13,external application of traditional Chinese medicine facial mask 12,and acupuncture 7.The most frequently used acupoints for bloodletting are Ashi(16 articles),Ashi(12 articles),Zusanli(7 articles),and Dahuang(9 articles),Huangqin(9 articles),Honeysuckle(9 articles),and Huangbai(9 articles).Clinical research section:Clinical symptom score:Compared within the group,there was a significant difference between the two groups before and after treatment(P<0.05);There was no significant difference between the two groups on the 14th day of treatment compared to each other(P>0.05);In terms of improving papules and pustules,there was a significant difference(P<0.05)between the experimental group and the control group on the 14th day of treatment.Visa Red Zone Score:Compared within the group,the experimental group showed a statistically significant decrease on the 14th day of treatment compared to before treatment(P<0.05);However,there was no statistically significant difference between the control group on the 14th day of treatment and before treatment(P>0.05).There was no statistically significant difference between the experimental group and the control group at each time point(P>0.05).RosaQoL score:Compared within the group,the experimental group and control group showed a statistically significant decrease on the 14th day of treatment compared to before treatment(P<0.05);There was no statistically significant difference between the experimental group and the control group before treatment,on the 7th day of treatment,and on the 14th day of treatment(P>0.05).Anxiety and depression scores:There was no statistically significant difference between the experimental group and the control group in both intra group and inter group comparisons.Safety analysis:During the treatment period,there were no significant adverse reactions observed in both groups.Conclusions:Literature research part:bloodletting,Chinese medicine solution soaking and acupuncture are widely applicable to all types of rosacea,while fire needle and Chinese medicine facial mask are particularly applicable to papular and pustular rosacea.Blood letting and fire needle focus on local stimulation and regulation,while acupuncture focuses on regulating the whole body with local acupoint selection,and local transdermal drug delivery of drug therapy achieves anti-inflammatory,bacteriostatic,insect killing,skin barrier repair,microcirculation improvement and other effects.The treatment of rosacea with external treatment of traditional Chinese medicine has a certain research enthusiasm,but there are still many shortcomings in current clinical research:no follow-up has been set up;Inclusion criteria do not limit subject classification or incomplete efficacy evaluation indicators;The quality of RCT methodology is not high.Looking forward to high-quality and rigorous RCT research in the future to provide more reliable evidence-based medical evidence for the treatment of rosacea with traditional Chinese medicine external treatment.Clinical research section:The combination of Liangxue Zhiyang Tang with LED yellow light and simple LED yellow light can improve clinical symptoms and have a certain clinical effect.Within a 14 day treatment cycle,the efficacy of the two is equivalent.However,the trend of decreasing clinical symptom scores in the experimental group is more significant than that in the control group.Moreover,the experimental group significantly improved papules and pustules in the short term compared to the control group.Cold compress with Liangxue Zhiyang Tang has certain clinical promotion value for papular pustular rosacea. |
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