| Technology innovation is the core of competence in pharmaceutical companies, technology innovation strategy command the innovative behavior. The pupose of this reaearch is to discuss the way and principles in the selection of technology innovation strategies in pharmaceutical companies.The methods used in this paper are literature review, expert consultanting, strategy analysis and case study. The issues studied included: the theory issues in the pharmaceutical innovation, the evolution, status and trend of the environment of global phmarmaceutical innovation, the influential factors and modes of pharmaceutical innovation, the starting point and the principles of selection of innovation strategies in pharmaceutical companies in our country.The main concluation are as follows. The productivity of new drug is descending; there is still some time to break through in new drug research and development; the increasing of development cost has become the bottleneck restraining the yield of drug development; the controlling of drug price and the encouraging competition of generics reduce the incentive effect to innovation; the protection of patent and test data promote innovation. Most governments are adjusting innovation strategy to raise innovation efficiency. The pharmaceutical industry of our country faces new opportunity and environment to develop. Imitative innovation is our main innovation mode at present, collaborating innovation is a essential path of innovation in our country, and the core pharmaceutical technology must depend on independent innovation. The innovation strategy selection in pharmaceutical companies in our country should base on the stage of improving technology. From overall situation, chemical and biopharmaceutical industry should apply Imitative innovation mode and think highly of breakthrough in important part. The companies of traditional Chinese medicine should emphasize the mode of independent innovation.
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