The Mechanism Of Fujian Tablet In Activating The Cerebral Area Of Functional Down-Regulation

Clinical practice has demonstrated that the patients of sequela of ischemic cerebrovascular disease may recover after treatment even though suffering from it for many years, which is relevant to the activation of the cerebral area of functional down-regulation.The thesis has investigated the mechanism of activation of the cerebral area of functional down-regulation combined with the recent development of neuroscience. It is believed that the activities and metabolization of the cerebral area decrease and the cerebral blood flow reduce and the activities of synapse also decrease remarkably (These pathophysiologic changes will still exist for many years since the infarction), because the cerebral area that was functionally closely linked with the cerebral infarct area formerly has no more communications with the infarct area after stroke. But the function of the cerebral area of functional down-regulation is relevant to the former function of the infarct area. If it is activated again, they will influence the recovery of nervous function. Activating the cerebral area of functional down-regulation provides a new therapeutic method. Therefore, based on the model of rat of sequela of ischemic cerebrovascular disease which has been adequately demonstrated and successfully set up, we apply the tutor's effective medicine- Fujian tablet, and make experimental study in these respects as follows: neurobehavioral assessment; measuring local cerebral blood flow; variance of the nerve plasticity and the expression of the protein relevant to the endodermis cells of cerebral microvessels, etc. The results show that the Fujian tablet could remarkably improve the nerve function of the model of rats and activating cerebral area of functional down-regulation is the important therapeutic mechanism.