Study On The Enriching Blood Effective Fraction Of Chinese Herbal Recipe--Siwutang (SWT)

Objective On the bases of investigation data , the paper had fixed the effective fraction of SWT about enriching blood action. Set up complete quality control system for the effective fraction. Carried out the studies on the mechanism of enriching blood. Methods The investigation was based on full recipe of SWT and separated all chemical components into three parts. During the sduty , Chinese traditional medicine chemistry, quality control as well as pharmacology was combined together closely. Result The paper had separated SFE-CO2 position, alcohol position as well as polysaccharides position, then analyzing the chemical component within them. Blood deficiency model according with hemogram characteristic of clinic "pattern" was set up , then the effective fraction of SWT was fixed. Set up complete quality control system for the effective fraction and carried out the research of Fingerprints. Carried out the studies on the mechanism of enriching blood by Serum pharmacology, Serum chemistry and pharmacodynamics test. Conclusion The paper determined the effective fraction of enriching blood about SWT which included polysaccharides. glycosides, organic acids and alkaloids.The quality standard of effective fraction provided basis for the validity of drug. Ferulic acid was defined as one of effective component by Serum chemistry. The result of Serum pharmacology showed that SWT and its effective fraction all can promote hyperplasia and differentiation of marrow cell .Study on pharmacokinetics provided parameters for clinic.