Study On Anti-tumor Effects Of Phenolic Alkaloids From Menispermum In Malignant Tumors Of Urinary System

Up to now, malignant tumors of urinary system are lack of effective drug treatment,especially for those in advanced stage. The morbidity of bladder carcinoma is maximal compared with other malignant tumours in urinary system,furthermore, bladder carcinoma is extremely easy to recur, As for renal cell carcinoma and prostatic carcinoma,symptoms appearance offen means fairly advanced stage. These cancers are often insensitive to chemotherapeutics commonly used in clinic, Prognosis is bad.Why do so many cancers resist to general drugs? One of the main reasons is that carcinomas with different biological characteristics possess natural and acquired drug resistance. Simple administration could not control disease effectively,so more new drugs or approaches are needed for us to select,especially those low-poisonous and high-performance agentias,such as traditional Chinese medicine. Extracting active component from herbs is tumor therapeutic tendency in the world. It's also our important subject to study.Many alkaloid from plants have important value in treatment and prevention of tumour. For instance,hydroxycamptothecine and paclitaxel have been widely used for treating liver cancer,bladder cancer and many other malignant carcinomas. Curative effects were satisfactory, moreover , there is no crossing drug-resistance.The mechanism of anti-tumor include controlling DNA synthesis, inducing apoptosis and cell toxic action.Asiatic moonseed rhizome,the traditional Chinese medicine, has bacteriostasis and blood pressure controlling efficacy. It also has effect against cardiac arrhythmia. Recently extracts of Menispermum dauricum were discovered to be anti-tumor effects, named Phenolic alkaloids of menispermum dauricum(PAMD)which can inhibit nasopharyngeal carcinoma...