The Association Between Coagulation System Activation And Risk Stratification Of Cerebral Infarction

Part I: The association between coagulation system activation and riskstratification of cerebral infarctionBankground:Cerebral infarction (CI) is a common cerebrovascular disease with high prevalence, recurrent, disability rate and high mortality. Age-specific cerebrovascular mortality has dramatically declined during the past 2~3 decades, due to the treatment of the traditional risk factors, such as hypertension, obesity, smoking, hyperlipidemia and diabetes mellitus et al.. However, there are still 30% individuals without traditional cardiovascular risk factors. Attention has shifted in recent years to the characterization and evaluation of novel phenotypic markers of cardiovascular disease, involving the coagulation and fibrinolytic systems, and inflammation.Activation of the coagulation system is a frequent finding in acute CI patients. Researches showed that the magnitude of hemostatic changes in acute CI may differentiate among different types of CI. The level of hemostatic activation may reflect the underlying mechanism of infarction. It may improve the outcome of CI and may provide new targets for CI treatment to explore the change profile of coagulation and fibrinolytic systems. Objects:(1) To characterize the abnormalities of coagulation system in both acute and convalescent CI patients , and compare levels of coagulation markers among different CI subtypes and prognosis.(2) To explore the association between the risk of CI and coagulation markers.(3) To evaluate protein Z level in general Chinese population, and examine the relationship between protein Z level and CI.Methods:A retrospective case-control study was carried out in PUMCH, in which 124...