Expression And Interaction Of P21WAF1/CIP1, P53, And Mdr-1 Genes In Human Bladder Carcinoma And The Clinical Significance

Bladder cancer(BC) is the most common malignance in urologic system, and the most of them (93.7%) is transitional cell carcinoma. Although tumor cells pathologic grade and clinical stage are usually used for appraising the malignant degre and prognosis of bladder carcinoma, the judgement may not overally reflect the biologic behaviors of tumor and results in some blind in present methods of therapy and prevement. Recent advances in molecular biology revealed that activation of oncogenesand loss of tumor suppressor genes are involved in the initiation and progression of bladder cancer. Although it has not been found alteration in special genomic DNA for bladder tumor up to day, the latest literature show that P53, Rb, mdr-1 and a newly cloned gene - P21WAF1/CIP1 has been regarded to be association with the malignant behaviors, chemotherapy response, and prognosis of bladder cancer.