An Experimental Study Of The Effect Of WAF1/CIP1 On The Growth And Apoptosis Of The Cell Of Esophageal Carcinoma

Esophageal cancer was one of the malighant neoplasms most frequantly encountered. Up to now, Molecular analysis showed that they were caused by alternation of oncogenes, antioncogenes and disorders of cell cycle control. Closely related to tumorigensis, Wild—type p53 —activated fragmentl/Cdk — interacting proteinl (WAF1/CIP1) acted as a antioncogen and a negative regulator in the cell cycle. In recent years, most attention was paid to the WAF1/CIP1 gene. Aimed at further exploring and demonstrating the molecular mechanisms and further gene therapy for esophageal cancer, this experiment study was carried out. The study consisted of five major parts including:1. The WAF1/CIP1 and P53 expression in 46 cases of esophageal squmouse carcinoma specimens were defected by immunohistochernistry. The results showed that the WAF1/CIP1 protein positive rate of esophageal carcinoma was 47. 8% and the positive rates in pathological grading ( Ⅲ relative ratio Ⅱ ,Ⅰ ) appeared to be obviously different (P<0. 01). Most of mutant P53 protein negative tissue had WAF1/CIP1 protein, and most of WAF1/CIP1 negative tissue had mutant P53 protein, which indicated that the mutant P53 could cause reduction or disppearance of WAF1/CIP1 in esophageal cancer and the expression WAF1/...