Studies On The Chemical Constituents And Bioactivities Of Sarcandra Glabra, Cercis Chinensis And Photinia Parvifolia

Sarcandra glabra (Thunb.) Nakai [syn. Chloranthus glabra (Thunb.) Makino] belongs to the genus Sarcandra of Chloranthaceae, which is distributed in Anhui, Zhejiang, Jiangxi. Fujian, Taiwan, Guangdong, Guangxi, Hunan, Sichuan, Guizhou and Yunnan Provinces. The whole plant was used as a drug for anticancer, antibacterial, antivirus and increasing the level of immunity. The result of bioassay displayed that the 70 % alcohol extract of Sarcandra glabra showed anti-inflammation and potent hepatoprotective activities.Cercis chinensis Bunge belongs to the genus Cercis of Leguminosae, which grows widely in southeast of China. The main components of the genus Cercis are flavornoids and aromatic compounds with antibacterial and anti-oxidation activities. In addition, the 95 % alcohol extract showed potent cyto-toxicities having been tested by Taisho Pharmacentical CO. LTD Japan..Photinia parvifolia (Pritz.) Schneid. belongs to the genus Photinia of Rosaceae, which is distributed in Henan, Jiangsu, Anhui, Zhejiang, Jiangxi, Taiwan, Sichuan, Guizhou, Guangdong and Guangxi Provinces. Although the genus comprises 60 species, among which only five plants were studied on their chemical constituents. The pharmacological screens in vitro disclosed that the EtOAc part of the 95% alcohol extract of Photinia parvifolia showed significant anticancer activity.By means of chromatography methods and spectral technologies, the three plants mentioned above were studied systemically in chemistry and related bioassays. Eighty compounds were obtained, in which 12 are new and 28 have remarkable hepato-protective, anticancer and anti-inflammation activities. We also synthesized new compounds 8. 9 and their aglycones.Forty five compounds were obtained from the 70% alcohol extract (30%, 70% alcohol elution fractions) from the whole plant of Sarcandra glabra, in which the structures of forty one were determined by spectroscopic analysis and chemical methods. As a result, there are 10 sesquiterpenoids (1-6, 12-15), 15 flavonoids (7-11,...