Study On The Chemical Constituents And Bioactivities Of Rhodomela Confervoides And Macaranga Adenantha

This thesis includes two main works. Firstly, the chemical constituents of polar portions of the ethanolic extract of Rhodomela confervoides, a red alga belonging to the Rhodomelaceae family, was investigated. Meanwhile, synthesis of two types of new compounds obtained from the alga was explored by using the co-occuring products as the starting materials. Secondly, the chemical constituents of the ethanolic extract of Macaranga adenantha, a plant belonging to the Euphorbiaceae family, was investigated. The results were listed below:1. By using middle pressure and high pressure liquid chromatographic technigues, and column chromatography over silica gel and Sephadex LH-20, 23 compounds were isolated from the polar portions of the ethanolic extract of R. confervoides. Of which structures of 22 compounds were identified, by spectroscopic methods including UV, IR, 1D NMR, 2D NMR, and MS, as 2-amino-3-(3-bromo-5-hydroxy-4-methoxyphenyl) propionic acid (1). 8-bromo-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (2), 8-bromo-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester (3), 6-bromo-8-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carb-oxylic acid methyl ester (4), 2,3-dibromo-4,5-dihydroxyphenylethanol (5), 2,3-dibr-omo-4,5-dihydroxyphenylethanol sulfate sodium salt (6), 3-dibromo-4,5-dihydroxyp-henylethanol sulfate sodium salt (7), 3-bromo-2-(2,3-dibromo-4,5-hydroxybenzyl)-4,5 -dihydroxyphenylethanol sulfate sodium salt (8), 9-[3-bromo-2-(2,3-dibromo-4,5-hyd-roxybenzyl)-4,5-dihydroxybenzyl]adenine(9), 2,3-dibromo-4,5-hydroxyphenylmetha-nol-4,7-disulfate potassium salt (10), 2,3-dibromo-4,5-hydroxyphenylmethanol (11), 2,3-dibromo-4,5-hydroxybenzyl methyl ether (12), 3-bromo-5-hydroxy-4-methoxyp-henyl-acetic acid (13), 3-bromo-5-hydroxy-4-methoxyphenyl-acetic acid methyl ester (14), 3-bromo-5-hydroxy-4-methoxybenzoic acid (15), 3,5-dibromo-4-hydroxybenzyl methyl ether (16), 2,2',3-tribromo-4,4',5,5'-tetrahydroxy-6'-methoxylmethyldiphenyl...