Experimental Study For Minimally Invasive Coronary Artery Bypass

Objective: To establish a new method of minimally invasive coronary artery bypass grafting (MICABG) by the support of left heart bypass. To observe the changes of hemodynamics in animal experiment and accumulate data for clinical application. To test the feasibility of complete revascularization with various bypass methods in multivessel disease. To confirm the significance of reducing invasion of MICABG by live blood analysis. To explore a special surgical instrument of MICABG and confirm its practicability by animal experiments.Methods: 16 mongrel dogs with weight from 15.0 ~ 23.0kg. In 10 dogs we assessed the exposure provided by a small left anterior incision (6~8cm) over the fourth intercostal space. In eight of ten animals, the left internal thoracic artery (LIMA) was dissected about 2cm from the chest wall, and a homogeneous carotid artery was anastomosed to the LIMA. In two other animals, a bifurcated homogeneous carotid artery was anastomosed directly to the thoracic descending aorta. Heparin was first administered about 0.5mg / kg and additional doses were given to maintain ACT about 200 seconds. After the pericardium was opened, exposed and explored the second obtuse marginal branch, and regional ischemic preconditioning was carried through. Left heart bypass was obtained by completing the...