Studies On The Effects Of Racemic And Optical Active 3-n-butylphthalide On Thrombosis Formation, Cerebral Microcirculation Dysfunction, And Inflammation Following Cerebral Ischemia And Its Mechanisms

Stroke is currently one of the most devastating public health problems. It is the second leading cause of death and the leading cause of serious long -term disability in our country. The costs associated with the acute treatment, long-term care, and lost productivity of stroke survivors are a significant burden to the individual and to society. Therefore, to clarify the causes and pathophysiology of stroke and to develop effective acute and preventive interventions is very important.PART I Effects of 3-n-butylphthalide on thrombosis formation and plateletfunction in ratsEvidence that platelets play an integral role in the pathophysiology of thromboembolic stroke is indisputable. Platelets normally contribute to clot formation and vascular repair. However, under pathologic conditions they participate in the formation of vascular-occluding thrombi and emboli. Therefore, acute and preventive treatments focus on platelets and other elements of the coagulation system. Antiplatelet preventive treatment that interfere with platelet activation and aggregation have dominated pharmacologic efforts to prevent stroke recurrence. The present study was designed to exploit effects of dl, I, d-NBP on their antiaggregating and antithrombotic activity with regard to in vitro platelet aggregation as well as ex vivo model of silk thread-induced thrombosis in an arteriovenous shunt. The generation of thromboxane A₂(TXA₂) and the...