The Function And Mechanisms Of TRF2 In Drug Resistance Of Gastric Cancinoma

The gastric cancer is one of the most prevalent malignant tumors in China. Chemotherapy is the major treatment modality currently available to improve patient outcomes, but treatment related toxicity and the emergence of resistance limit their effectiveness. Hence there is an urgent need to develop new treatment strategies. Most anticancer-drugs exert their toxicities depending on DNA damage. Efficient DNA repair in the cancer cell is an important mechanism for therapeutic resistance. Inhibition of DNA repair has the potential to enhance the efficacy of currently available DNA damaging agents and several novel drugs targeting specific DNA repair proteins such as MGMT inhibitors, PARP inhibitors and methoxyamine have shown promising prospect in combination with chemotherapy or irradiation.Mammalian telomeres are specialized DNA-protein structures localized at the ends of chromosomes. They are composed of repeated hexanucleotides TTAGGG bound by a large number of telomere-binding proteins. A complex formed by six telomere-specific proteins TRF1, TRF2, POT1, TIN2, TPP1 and Rapl are called shelterin which protect the chromosome end. TRF1 and TRF2 are two major telomeric proteins...