The Pathogenesis Study Of Post Stroke Depression And The Development Of Its Mouse Model

In terms of morbidity, mortality, and money spent, the cost of Neurologic and Psychiatric disorders to society is phenomenal. Stroke represents the number one cause of disability and the 3rd leading cause of death in the World, while ten percent of the population experiences at least one major depressive episode (one of the most prevalent affective disorders) during life. Post stroke depression (PSD) is a common and severe complication after stroke with incidence of 20%-50%, but neither the exact effects of stroke on development of PSD nor the differences of characters between PSD and nonstroke depression have been elucidated definitely, and so it is necessary to elaborate the pathogenetic valid methods for their efficient therapy based on knowledge of the pathogenetic mechanisms of these illness. Owing to the limitation of studying neurochemical and neurobiological mechanisms of PSD in humans, the search for, validation and application of adequate animal models of the human affective disorders is very important. At present, though several animal models of depression are known, which can be divided into several types: stress models, separation models, social models, pharmacological models and miscellaneous models , no suitable animal model of PSD is available. Both this fact and chemical heterogeneity of different forms of depression determine that there is a continuing need for novel animal models of PSD, which are different from the present animal...