| Study on current protocols for CIN treatment and post-operative follow up and the value of p16INK4a and HPV hybrid capture II used in diagnosis for CIN and post-treatment follow-upBACKGROUNDWith the rapidly development of cytology screen technology, it makes it possible for early diagnosis cervical precancer before it change into cancer. Meanwhile, the main treatment modalities for the management of histological proven CIN, such as CO2 laser vaporization and conization have been the most effective methods for CIN, especially for young women who want to keep their fertility. But recurrence of CIN after local treatment indicates the necessary and importance for understand the risk factors related to recurrence for surveillance patients. It was reported that the factors effect the relapse of CIN were complicated and multi-factors.The procotols for post-operative follow up is the focus on this field at present .How to improve the accuracy of the screening methods for follow up and find the group people with high risk factors for recurrence and reduce the frequencies of low risk group of patients are very important.The incidence of adenocarcinoma now account for as many as 19% of all cervical cancers. One of the reason is that cervical screening is less effective at preventing cervical adenocarcinoma than squamous carcinoma. Adenocarcinoma or ACIS is also significantly related to HR-HPV infection. Epidemiological investigation showed that the incidence of ACIS among reproductive women was high. Therefore, ASCCP and Australia National Cervical Intraepithelial Neoplasma Diagnosis and Treatment guidelines suggest that conservative operation can be performed on young women with ACIS or adenocarcinoma LA (1) desiring to keep their reproductive capactivity, hysterectomy is recommended for young women who already have completed child bearing. If the margins of the initial cone biopsy are involved by ACIS, then a further...
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