The Significance Of Inflammation-Related Cytokines Expression In Kidney Of Diabetic Rats And The Drug Intervention Study

Objective and Background: Diabetic nephropathy (DN) is one of the most common and serious chronic complications of diabetes mellitus (DM). With the rising tendency of DM incidence, DN has become one of the principle causes of end stage renal disease (ESRD). And consequently, the medical expenditure of following dialysis treatment and kidney transplantation is increasing every year and brings great economic burden on the patients as well as our whole society. The pathologic characteristics of early DN are the enlargement of glomerulars, thickness of basement membrane and the accumulation of extracelluar matrix (ECM) in mesangial region. The characteristics of the advanced stage are glomerular sclerosis and interstitial fibrosis.The etiological factors and pathogenesis of DN are still not fully understood. Currently it is commonly regarded that the hemodynamic disorder and the consequences of metabolic disorder caused by high glucose are the basic reasons for renal injury. But the evidence-based medicine (EBM) proved that most of those DN patients still progress to the terminal stage of renal failure even with very tight glycemic control and renin-angiotensin system(RAS) blocked by angiotensin converting enzyme inhibitor(ACEI) or angiotensin II receptor blocke (ARB). Therefore, in order to improve our prophylaxic and cure ability, we have to search for new therapeutic strategies to satisfy the need of multipath and combined therapy. Recent researches have revealed that inflammation is the key factor of DN progression besides metabolic disorder and hemodynamic changes. Regional RAS is very important in changing renal hemadynamics in the early stage of DN, and can accelerate the...