| Under the guidance of Professor Guo Weixing, together with the knowledge of both basic theory of TCM and modern medicine, the author puts forward a pathogenesis hypothesis based on the clinical characteristic of early stage damage of kidney caused by EH, which is deficiency of kidney Qi, imbalance between Yin and Yang of the kidney as well as blood stasis in kidney collaterals. The author formulated a preparation PingShenTongLuoJiangYa granule which is used to tonify kidney qi, make a balance between kidney yin and yang, and promote the circulation of blood to remove collaterals obstruction in the kidney. The author has done research to evaluate the treatment effect and the mechanism of decreasing the blood pressure and protecting the kidney through clinical observation and animal testing. The result shows that the study group has achieved a good result in lowering the blood pressure smoothly, improving the signs and symptoms of the patients, such as vertigo, tinnitus, weakness in waist and knees, hypodynamia and so on, reversing the damage of kidney, adjusting the cholesterol level, lowering the viscidity of blood as well as improving safety and lowering adverse effects. In animal testing , we have found out that the granula can lower the blood pressure of SHR rats with some effect of slowing down the heart rate and improving tranquility , descending plasma ET-1 and ascending serum ON , inhibiting the activity of RAS system , improving the level of sexual homeostasis and pathological renal injurie . The conclusion is that the PingShenTongLuoJiangYa granula has the effect of lowering blood pressure stably and mildly, protecting kidney damaged by EH, improving the clinical signs and symptoms. It has been proven to be a useful formula having good effect through several links and target points. This research deeps the TCM comprehension to mechanism of kidney damage of EH , puts forward a new research way and a recipe , makes a good try for TCM to thetreatment of hypertension .
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