Study Of The Relationship Between Angiogenesis Of Breast Precancerous Change And Differentiation Of Symptoms And Signs

Objective: A study was conducted to screen the high-risk breast precancerous crowd , determine the essence of breast precancerous change from the view of angiogenesis, in order to provide a objective criterion for differentiation of symptoms and signs of tradional chinese medicine (TCM). And to discuss the relation between differentiation of symptoms and signs and angiogenesis. Methods:300 patients of high-risk breast precancerous chosen in random were grouped into four in tcm types, combining high risk factor,breast molybdenum target, Color Doppler Flow Imaging (CDFI)together to biopsy and pathohistology analyse,screening precancerous disease. To observe whether hemodynamics index , BIRADS grade, pathohistology can reflect differentiation of symptoms and signs and whether can accord with pathogenesis regularity. of the total 60 patients study the expression of MVD,VEGF,FLK,p53,CerbB-2 after biopsy and relationship between them and pathological character. Results: The accumulation of phlegm and blood stasis is the main pathogenesis when pathohistology have progress to breast precancerous stage, comparing with stagnation of QI due to depression of the liver type and chong-ren-disorder type, the phlegm-stasis type(partial depression of the live and partial chong-ren-disorder) have higher hemodynamics index such as Vmax(maximum rate of clearance)and RI (resistent index),III,IV,V grade have more portotin of BIRADS grades,and according with have more propotion of precancerous lesion, more counts of MVD, and higher expression of VEGF,FLK,p53,CerbB-2(P<0.05)。According with the proceeding of hyperplasy stage--precancerous lesion stage--invasive breast cancer stage, higher expression of MVD,VEGF,FLK,p53,CerbB - 2 is observed. And the tendency also can obtained successively in the development of precancerous lesion( Intraductal papillomatosis, Atypical hyperplasia--ductal carcinoma in situ I , II grade--ductal carcinoma in situ III grade) .Conclusion: most of mammary precancerous lesion are phlegm-stasis type,and the expression of angiogenesis factors is higher. pathological characters and expression of VEGF,bFGF,MVD can be considered the criterion in studying the tcm types , and estimating the treatment. Which can reflect differentiation of symptoms and signs and accord with pathogenesis regularity. Angiogenesis and regulating factor reflect the malignant tendency of precancerous lesion. Combining hemodynamics index, BIRADS grade with microbiopsy is an effective method of screen mammary precancerous lesion.