The Effect Of Homeobox Genes On Oncogenesis And Differentiation Of Human Oral Squamous Carcinoma

Purpose:Homeobox genes represent a family of transcription factors. This family regulates cell proliferation and differentiation precisely during the early development of bacteria and almost all eukaryotic organisms. They also partially determine the location of mesoblastic segments and development of adult organs. Because of their involvement in regulation of cell proliferation, differentiation and cell cycle, the homeobox genes must have an important role in oncogenesis. Numerous reports have demonstrated that homeobox genes have relationship not any with developmental malformation, but also the oncogenesis and evolution. However, as we know there is still no report about the effect of homeobox genes on oncogenesis of OSCC. This study is purposed to search for the potential oncogenic homeobox gene in OSCC, and to study its effect on oncogenesis and differentiation.