Regulative Effect And Its Mechanism Of Chinese Traditional Medicine With Warming-yang Effect On The Imbalance Of Collagen Metabolism Of Lung Tissue In Blemycin-induced Rat Pulmonary Fibrosis

Backgroups: The patients with a refractory disease such as idiopathic pulmonary fibrosis (IPF) have had again a chance for being cured as the Traditional Chinese Medicine (TCM) and its medicine have got a rapid progress on modernization research in the last decade, and an effective therapeutic method that would reverse and prevent the the disease course of IPF could not be got up to now. In addition, the essence of the renal-yang asthenia syndrome have been confirmed as a hypofunction of the hypothalamus-pituitary-target-gland axes(thyroid,adrenal,gonad,thymus gland), of course, it would lead to the imbalance of matter metabolism such as collagen metabolism in the body; and the pathological pathogenesis of IPF is mainly the imbalance of external cell matrix (ECM) metabolism and its over-deposition in the lung, but, the relation between the renal-yang asthenia and ECM metabolism remains to be unknown.Objective: To investigate the imbalance of collagen metabolism and its mechanism in the lung of the rat with renal-yang asthenia and pulmonary fibrosis, and the effects of Cordyceps sinensis powder on pulmonary fibrosis, in order to provide the evidence for research and development of medicine of anti-fibrosis in the lung from Chinese Traditional Medicine with...