Effects Of Jiangzhi Xiaoban Pill On Treatment Of Patients With Angina Pectoris Caused By Phlegm-heat And Blood Stasis And Experimental Research In Quail With Atherosclerosis And Hyperlipidemia Model

Objective:To observe the therapeutic effects of Jiang Zhi Xiao Ban Pill(JZXBP) on patients with angina pectoris caused by phlegm-heat and blood Stasis and experimental research in quail with atherosclerosis and hyperlipidemia model to explore its potential pharmacological mechanism.Methods:1. To select 60 eligible inpatients, who has angina pectoris caused by phlegm-heat and blood Stasis, and they all have been treated by the cardiovascular medicine department and outpatients, the 1st hospital affiliated to Hunan university of TCM, from July 2009 to July 2010. Then divide them into two groups randomly, the ZhiJiangNing pill controlled group (A)and the group treated by JZXBP(B). After 8 weeks treatment, observe the changes of syndromes, angina pectoris, ECG and the rate of nonused or decreased Nitroglycerin, as well as the indexes such as TC, TG,LDL-C, HDL-C,ApoA1, ApoB,hs-CRP,TNF-αand IL-6. 2.120 quails were randomly divided into normal group(20) and high lipid group(100).Models of hyperlipidemia and atherosclerosis in quails was built with high cholesterol diet in 7 weeks. They were randomly divided into 6 groups:normal group,high lipid group, Simvastatin group,Zhi Jiang Ning Pill group,JZXBP 0.39 g/kg group,JZXBP 0.78 g/kg group, JZXBP 1.56g/kg group.The levels of plasma total cholesterol (TC), triglyceride (TG),low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol(HDL-C), apolipoprotein A(ApoA) and apolipoprotein B (ApoB),Leptin,PLA2,C reactive protein(CRP),TNF-a, IL-6,changes of the atherosclerotic plaque of aorta and coronary artery were observed.Results:1. The mended rate of syndrome in group B is 90.00%, while 83.33% in group A. There has statistical differences between the two groups(P<0.05). The total effective rates of curative effects of angina pectoris,ECG,decreases in the dose of Nitroglycerinin group B are 86.67%,73.33% and 86.67% respectively,while76.67%,53.33% and 70. 00% in group A respectively.They both have significant differences between the two groups(P<0.05).While the indexes such as TC,TG, LDL-C,HDL-C,ApoA1,ApoB,hs-CRP,TNP-αand IL-6 in group B compar-ed with group A, the differences is significant (P<0.05 or P<0.01).2.JZXBP group had remarkable decreases in the level of serum TC,TG,LDL-C,ApoB,Leptin,PLA2, (P<0.05 or P<0.01), and increases in the level of serum ApoA and ApoA/ApoB (P<0.05 or P<0.01). JZXBP 0.78 g/kg,1.56 g/kg group could evidently lower the level of serum CRP, TNF-αand IL-6 (P<0.05 or P<0.01).The number of atherosclerotic plaques of aorta and coronary artery,were significantly less in the JZXBP pill than that in the model group (P<0.05),what correlates with its dose and period of treatment (P<0.01 or P<0.05).Conclusion:JZXBP could play a stronger role in regulating blood lipid and decelerating the progression of atherosclerosis and eliminating (or stabilize) atherosclerotic lipid plaque,probably by decreasing the levels of CRP,TNF-αand IL-6 in tandem inhibiting inflammatory reaction in endangium and regulating lipometabolism and the abnormality of blood lipid.