Naolisu Capsule Improve Rat Experimental Study Of The Mechanism Of Action Of Cognitive Impairment In Vascular Dementia

Objective: To study the action mechanism of NLS capsule which can decrease ischemia agnosia for vascular dementia rats. Methods: Vascular dementia model rats were established by a 2-vessel occlusion(2-VO) method. These vascular dementia rats were randomly classified into six groups, namely, model group(M),control group(X),NLS capsule high group (Nl) NLS capsule middle group (N2) NLS capsule low dos group(N3) and pseudo-operation group(J).After 7 days treatment, water maze were used to test the learning and memory abilities of these Wistar rats. Observe the pathologocial changes of their cerebral tissues, determine the content of CGRP in serum and AchE in hypomnesia,studied the positive SS and NOS neurons in hypomnesia by immunohistochemical method. Results: From this experiment, the following results could be observed. First, the learning and memory abilities of rats in X group Nl and N2group were better than that of other group rats(P < 0.01).Content of endothelin(ET-1) decreased in serum .otherwise, serum CGRP and AchE of hypomnesia increased( P < 0.01) . Somatostatin (SS) activities ascented by large margin, NOS levels reduced remarkably (P<0.01) .Conclusions: NLS capsule could inhance the learning and memeroy abilities of vascular dementia rats, the mechanism of NLS capsule may be : regulate the level of CGRP and ET-1 in serum, inhibiting expression of NOS which aroused cerebral apotosis, stimulating cerebral tissues to make out SS, raising the function of Ach system.