Integrative Treatment Of Advanced Non-small Cell Lung Cancer With Analysis Of Retrospective Clinical Study

Lung cancer is the most commonly seen malignant tumor. Among which, 80% arenon-small-cell lung cancer (NSCLC); most of the patients are already in the advanced stage (stageIIIB and stage IV) when diagnosed. The primary problem of treating advanced NSCLC is how toincrease the response rate of chemotherapy, extend survival time, and improve quality of life.The use of TCM in treatment of advanced NSCLCis gaining more and more attention today.However, there is still a lack of polycentric, big sampling, and standardized clinical data to provethe advantage of TCM intervention in the treatment of advanced NSCLC and to determine itsbenefits to overall treatment. In sight of this problem, we attempted to make a retrospectivestudy of patients admitted to the hospital after 1st of January of 1998, ages from 18 to 75, who hadundergone standardized treatment of integrated traditional Chinese medicine and western medicine(integrated TCM and WM) or western medicine alone. Our research studied the immediate andlong-term effects and some economic indices. Data of research are from 203 cases of advanced NSCLC from 7 first-grade, first-classBeijing hospitals, totaling to 243 times of hospital confinement. Among which, 88 belong tointegrated TCM and WM group and 115 belong to the WM group. Results show: ①CR+PR ofboth groups are 35.34% and 22.05% for WM group and integrated TCM and WM group,respectively, showing significant statistical difference (P<0.05). Results prove that the WMgroup have better immediate effects. ②CR+PR+NC of both groups are 78.45% and 83.46%for WM group and integrated TCM and WM group, respectively, showing no significant statisticaldifference (P>0.05) but the integrated TCM and WM group show some trend of increase. ③thecost effectiveness ratio(C/E) of both groups are 816.15 and 582.91 for WM group and integratedTCM and WM group, respectively, showing that the integrated TCM and WM group is better thanthe WM group, results prove to exist after sensitivity analysis. ④52.76% of patients belongingto the integrated TCM and WM group had increased KPS after treatment, while 42.52%maintained a stable KPS. As for the WM group, only 16.98% had increased KPS after treatment,62.26% did not have any significant changes. When comparing the performance status of bothgroups, results show a significant statistical difference (P<0.0001). ⑤When comparing the painrelieving effectiveness of both groups, CR+PR scores are 83.93% and 60.72% for WM groupand integrated TCM and WM group, respectively, showing a significant statistical difference,which proves that the former is better than the latter. ⑥The median survival duration of bothgroups are 304 days and 354 days for the WM group and integrated TCM and WM group,respectively, showing no significant statistical difference (P>0.05). ⑦The 1-year and 2-yearsurvival rates of the WM group are 17.39% and 5.22%, respectively, while 38.64% and 14.77%for the integrated TCM and WM, respectively, showing a significant statistical difference(P<0.05), with the integrated TCM and WM group proven to be better. 3-year and 5-yearsurvival rates of the WM group are 2.61% and 0.0%, respectively, while 6.82% and 1.14% forthe integrated TCM and WM group, respectively, with the integrated TCM and WM group provento be better, but not showing a significant statistical difference. The time to progression(TTP)of both groups are 123 days and 175 days for the WM group and integrated TCM and WM group,respectively. The latter has a trend of extension but not showing any significant statistical英文摘要(Abstract) 3difference. ⑧The deficiency of qi and yin syndrome and the stagnation of phlegm and bloodstasis syndrome are the most commonly seen syndromes, each taking up 35.43% of the total cases.⑨TCM treatment principles include invigorating qi and yin (59.84%), strengthening the spleenfor eliminating dampness (27.56%), promo...