The Northeast Crassirhizoma, Chemical Constituents Of Ardisia And White Silver Back Rattan Research

Dryopteris crassirhizoma Nakai (Dryopteridaceae) is distributed mainly in the northeast of China, which rhizomes (common name: Dong-Bei-Guan-Zhong) are widely used as a traditional Chinese medicine for the treatment of intestinal worms, fever caused by influenza and vomiting of blood. Phloroglucinol derivatives and flavonoid glycosides have been reported from the rhizomes of D. crassirhizoma, and have demonstrated antibacterial, antitumor-promoting, antioxidant and HIV-1 reverse transcriptase inhibitory activities. A phytochemical investigation on the rhizomes of D. crassirhizoma Nakai resulted in the isolation of ten compounds. Their structures were established as 1-butanoyl-3-C-β-D-glucopyranosyl-5-methyl-phloroglucinyl-6-O-β-D-glucopyranoside (1) , 4β-carboxymethyl-(-)-epicatechin ( 2 ) , isobiflorin ( 3 ) , biflorin ( 4 ) , 1-β-D-glucopyranosyloxy-3-methoxy-5-hydroxybenzene (5) , (-)-catechin-6-C-P-D-glucopyrano-side ( 6 ) , kaempferol-3-O-α-L-rhamnopyranosyl-7-O-α-L-rhamnopyranoside ( 7 ) , kaempferol-3-O-α-L-(3-O-acetyl)rhamnopyranosyl-7-O-α-L-rhamnopyranoside (8) , kaempferol-3-O-α-L-(4-O-acetyl)rhamnopyranosyl-7-O-α-L-rhamnopyranoside (9) , matteuorienate A (10) . Among them, compounds 1 was the new compound, compounds 2-6 were isolated from the genus for the first time.Ardisia japonica (Thunb.) Bl. (Myrsinaceae) is widely distributed in Southeast Asia and North America. It has been used in the treatment of cough and uterine bleeding in traditional medicine and has shown significant anti-HIV activity in modern pharmacological studies. A chemical investigation on A. japonica resulted in the isolation of 21 triterpene saponins. They were identified as ardisianoside A (11), ardisianoside B (12), ardisianoside C (13), ardisianoside D (14), ardisianoside E (15), ardisianoside F (16), ardisianoside G (17), ardisianoside H (18), ardisianoside I (19), ardisianoside J (20), ardisianoside K (21), 3β-O-{α-L-rhamnopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-{O-P-D-glucopyranosyl-(1→2)}-α-L-arabinopyranosyl}-16α-hydroxy-13β,28-epoxy oleanane (22), ardisicrenoside A (23), cyclamin (24), ardisiacrispin B (25), 3-O-(α-L-rhamnopyranosyl-(1→2)-P-D-glucopyranosyl-(1→4)-α-L-arabinopynanosyl) cyclamiretin A (26), primulanin (27), ardisiamamilloside H (28), ardisiamamilloside F (29), ardisiamamillosede C (30) and ardisicrenoside G (31). Among them, 11-21 were new compounds.Argyreia seguinii Levl (Convolvulaceae) is distributed in Southeast Asia. It has been used in the treatment of blood stanching. A chemical investigation on A. seguinii resulted in the isolation of 11 known compounds. They were identified as β -sitosterol (32),stigmasterol (33), daucosterin (34), scopoletin (35), salicylic acid (36), 3,4-dihydroxy benzaldehyde (37), N-trans-p-...