Cerebral Infarction After Experimental Study Of Neural Stem Cells In Situ Activation And Proteomics

Cerebral infarction is a common ischemic cerebrovascular disease with high morbidity and mortality rates. Neuron death is inevitable for most cerebral infarction patients. Neural stem cells have the potential of self-renewal and can proliferate then differentiate into neurons and astrocytes under some condition, neural stem cells may be involved in neuronal function restoration. It was assumed that after maturation, the central nervous system is incapable of regenerating after injury. However, recent studies demonstrated neural stem cells exist in the central nervous system of adult mammals including human beings, and most of neural stem cells were at resting stage in vivo.Studies indicate possible activation of self neural stem cells under pathological conditions such as injury and further proliferate, migrate and differentiate such that damaged function due to injury might be restored. This method is helpful to solve origin of neural stem cells, has not ethic debate and immunoreaction, which is an ideal approach to treat cerebral infarction with neural stem cells. The molecular mechanisms underlying increased proliferation and differentiation of neural stem cells after cerebral infarction still remain unclear and need to be elucidated to aid development of a novel strategy for enhancing neurogenesis in stroke patients.Proteomics offers a promising way for its capability of elucidating pathogeny mechanisms of serious illness.In this study, we observed the reaction process of neural stem cells, studied the relations of proliferated neural stem cells and protein expression, hoped to elucidate...